Omnipaque Versus Gastroview as Oral Contrast for Abdominal and Pelvic CT
Information source: University of Alabama at Birmingham
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy
Intervention: Omnipaque (Drug); Gastroview (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: University of Alabama at Birmingham Official(s) and/or principal investigator(s): Michelle McNamara, MD, Principal Investigator, Affiliation: University of Alabama at Birmingham
Summary
Patients who are scheduled by their health care provider for routine computed tomography
(CT) scan will be asked to participate in this study. The primary purpose is to determine if
there is a difference in patient preference for Omnipaque versus Gastroview as oral contrast
for abdominal pelvic CT. A secondary objective is to evaluate if there is significant
difference in bowel opacification for the two agents.
Clinical Details
Official title: Omnipaque Versus Gastroview as Oral Contrast for Abdominal and Pelvic CT
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Diagnostic
Primary outcome: Preferred Contrast Agent
Secondary outcome: Bowel Opacification Score
Detailed description:
Participants must be scheduled for a CT scan prior to enrollment in this study. Informed
consent will be obtained from patients acceptable to be included in the study. It will be
noted if there is a history of gastrointestinal surgery and if the patient is nauseated
before the contrast is administered.
Patients will be randomized to receive either a standardized dilution of Gastroview or
Omnipaque orally. The two agents will be prepared to have nearly equivalent iodine
concentration. No flavoring agent (ie Crystal Light) will be added. The plan is to mix the
agents per manufacturer recommendation as follows:
Omnipaque 350 26cc in 974 cc of water (9. 0g iodine) Gastroview 25cc in 1000cc of water
(9. 17g iodine)
The time the patients start and stop consuming the contrast as well as the volume taken and
time from first drink to start of the scan will be recorded by a blinded investigator.
Patients will be asked to drink 900cc. Technical staff will report any side effects or
complications observed.
After completion of the CT scan, patients will fill in a survey rating the taste of the
agent on a 5 point scale, and will be asked to report any side effects. Planned rating scale
is as follows:
- 2=Dislike very much
- 1=Dislike moderately 0=Neither like nor dislike
- 1=Like moderately
- 2=Like very much
A taste test between the two agents will then be administered by a blinded investigator.
Patients will be given 30 cc of each agent. The order in which the agents are administered
will be randomized. Patients will be asked to rate preference, if any, for either agent on a
3 point scale. Potential bias related to which agent was administered for the CT will
analyzed from the data.
Planned rating scale is as follows:
- 1- A is better 0 -no difference
- 1- B is better
Patients will be contacted by telephone the day after the CT to assess for any delayed side
effects such as diarrhea, constipation, and abdominal cramping experienced in the 24 hours
following.
Bowel opacification will be rated by 2 body imagers blinded to the agent the patient
received. Degree of opacification of the stomach, duodenum, jejunum, and ileum will be rated
on a 4 point scale. If contrast has reached the colon, ascending, transverse, descending and
sigmoid will be similarly evaluated. Four point rating scale is as follows:
0= absent opacification
1. minimal (<25% of analyzed segments opacified)
2. good (>25 % and < 75% of analyzed segments opacified)
3. excellent (> 75% of analyzed segments opacified)
Description of tests/procedures to be performed. Patients will undergo contrast enhanced
abdominal pelvis CT as ordered by the referring clinician. Patients will be randomized to
either dilute Omnipaque or dilute Gastroview for oral contrast. Both agents will be in a
concentration of 9 mg of iodine/ml, and a volume of 900 cc.
Eligibility
Minimum age: 19 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients at least 19 years of age scheduled for outpatient contrast enhanced
abdominal pelvic CT at The Kirklin Clinic in Birmingham Alabama as part of clinical
care with the patient's provider will be screened for eligibility.
Exclusion Criteria:
- Not competent to give consent.
- Pregnant.
- Known allergy to either of the contrast agents.
- Loss of sense of taste or smell.
- Contraindication to oral administration such as aspiration risk.
Locations and Contacts
The Kirklin Clinic, Birmingham, Alabama 35249, United States
Additional Information
Starting date: August 2007
Last updated: May 19, 2010
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