The objective of this study is to evaluate the effect of memantine versus placebo on
functional communication in patients with Alzheimer's Disease
Minimum age: 50 Years.
Maximum age: N/A.
Gender(s): Both.
Inclusion Criteria:
- Male and female outpatients, 50 years or older, native English speakers, meeting
National Institute of Neurological and Communicative Disorders and
Stroke--Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria
for probable AD with a Mini Mental State Examination (MMSE) score of 10 to 19 at
Screening and Baseline
Exclusion Criteria:
- Current Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition
(DSM-IV) Axis I disorder other than AD
- Previous imaging results not consistent with the diagnosis of AD
- Modified Hachinski Ischemia Score greater than 4
- Evidence of other neurologic disorders
- Clinically significant systemic disease
- A known or suspected history of alcohol or drug abuse in the past 5 years
- Taking excluded medication
- Previous treatment with commercial memantine
Forest Investigative Site, Christchurch 8022, New Zealand
Forest Investigative Site, North Shore 0622, New Zealand
Forest Investigative Site, Timaru 8022, New Zealand
Forest Investigative Site, George, E. Cape 6529, South Africa
Forest Investigative Site, Port Elizabeth, E. Cape 6014, South Africa
Forest Investigative Site, Johannesburg, Gauteng 2052, South Africa
Forest Investigative Site, Johannesburg, Gauteng 4001, South Africa
Forest Investigative Site, Pretoria, Gauteng 0182, South Africa
Forest Investigative Site, Durban, KZ-Natal 4001, South Africa
Forest Investigative Site, East Gosford, New South Wales 2250, Australia
Forest Investigative Site, Hornsby, New South Wales 2077, Australia
Forest Investigative Site, Kogarah, New South Wales 2217, Australia
Forest Investigative Site, Newcastle, New South Wales 2300, Australia
Forest Investigative Site, Randwick, New South Wales 2031, Australia
Forest Investigative Site, Chermside, Queensland 4032, Australia
Forest Investigative Site, Toowoomba, Queensland 4350, Australia
Forest Investigative Site, Adelaide, South Australia 5000, Australia
Forest Investigative Site, Woodville, South Australia 5011, Australia
Forest Investigative Site, Box Hill, Victoria 3182, Australia
Forest Investigative Site, Frankston, Victoria 3199, Australia
Forest Investigative Site, Heidelberg West, Victoria 3081, Australia
Forest Investigative Site, Kew, Victoria 3101, Australia
Forest Investigative Site, Cape Town, W. Cape 7500, South Africa
Forest Investigative Site, Cape Town, W. Cape 7530, South Africa
Forest Investigative Site, Perth, Western Australia 6001, Australia