Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis
Information source: Fudan University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: C.Delivery; Surgery (Previous), Gynecological
Intervention: rocuronium (Drug); cisatracurium (Drug)
Phase: N/A
Status: Not yet recruiting
Sponsored by: Fudan University Official(s) and/or principal investigator(s):
Shaoqiang Huang, doctor, Principal Investigator, Affiliation: Obstetrics and Gynecology,Fudan University
Summary
The investigators investigated whether laparoscopic versus open surgical approaches affected
the pharmacokinetic and pharmacodynamic of a single bolus dose of rocuronium or
cisatracurium.
Clinical Details
Official title: Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis.
Study design: Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)
Primary outcome: the blood flow in the right and middle hepatic veins
Secondary outcome: the plasma Concentration of rocuronium and cisatracurium
Eligibility
Minimum age: 18 Years.
Maximum age: 60 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- American Society of Anesthesiology 1-2
- BMI 18-30 kg. m-2
- elective gynaecological operations under general anaesthesia
Exclusion Criteria:
- cirrhosis
- hepatitis
- hepatoma
- heart failure
- arrhythmia
- renal dysfunction
- electrolyte disturbances
- acid-base imbalances
- neuromuscular disorders
Locations and Contacts
Additional Information
Starting date: November 2014
Last updated: July 16, 2014
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