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Everolimus, Carboplatin, and Etoposide in Treating Patients With Small Cell Lung Cancer or Other Advanced Solid Tumors

Information source: University of California, Davis
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific

Intervention: carboplatin (Drug); etoposide (Drug); everolimus (Drug); Correlative studies (Other)

Phase: Phase 1

Status: Terminated

Sponsored by: University of California, Davis

Official(s) and/or principal investigator(s):
David Gandara, MD, Principal Investigator, Affiliation: University of California School of Medicine - Davis


RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as carboplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) together with everolimus may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of everolimus, carboplatin, and etoposide in treating patients with small cell lung cancer or other advanced solid tumors.

Clinical Details

Official title: Phase I Trial of Carboplatin and Etoposide in Combination With Everolimus (RAD001) in Advanced Solid Tumors, With Emphasis on Small Cell Lung Cancer (SCLC)

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Safety and feasibility

Secondary outcome:

Maximum-tolerated dose as assessed by NCI CTCAE, Version 3.0

Dose-limiting toxicities and toxicity profile as assessed by NCI CTCAE, Version 3.0

Efficacy of this regimen in patients with small cell lung cancer

Pharmacokinetic parameters

Exploratory biomarker analysis

Detailed description: OBJECTIVES: Primary

- Determine the safety and feasibility of everolimus combined with carboplatin and

etoposide in patients with advanced solid tumors, with emphasis on small cell lung cancer (SCLC). Secondary

- Determine the maximum-tolerated dose of this regimen in these patients.

- Describe the dose-limiting toxicities and toxicity profile associated with this regimen

in these patients.

- Determine, preliminarily, the efficacy of this regimen in an expanded cohort of

patients with SCLC.

- Assess the pharmacokinetic parameters of everolimus in this combination.

OUTLINE: This is a dose-escalation study. Patients receive oral everolimus on days 1-21, carboplatin IV over 15-30 minutes on day 1, and etoposide IV over 30 minutes on days 1-3. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients in the expanded cohort undergo blood collection on days 1, 15, and 22 for pharmacokinetic studies by liquid chromatography-tandem mass spectrometry. After completion of study therapy, patients are followed for 30 days.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.



- Histologically or cytologically confirmed advanced solid tumors for which curative

standard treatments are not available

- Ten additional patients with extensive stage small cell lung cancer are accrued

to the expanded cohort once a maximum tolerate dose (or a dose for further exploration) is determined

- Must be chemotherapy naive

- Measurable or evaluable disease

- Prior irradiated disease sites are considered measurable if there is clear

disease progression following radiation therapy

- No uncontrolled brain or leptomeningeal metastases (including those requiring


- Zubrod performance status 0-2

- Life expectancy > 3 months

- Granulocyte count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Creatinine ≤ 1. 3 mg/dL OR creatinine clearance > 40 mL/min

- Serum bilirubin ≤ 1. 5 mg/dL (regardless of liver involvement)

- SGOT ≤ 3 times upper limit of normal (ULN)

- INR ≤ 1. 3 (≤ 3 if on anticoagulation)

- Fasting serum cholesterol ≤ 300 mg/dL*

- Fasting triglycerides ≤ 2. 5 times ULN*

- No severe and/or uncontrolled medical co-morbidities or other conditions that could

affect participation in the study including, but not limited to, the following:

- Unstable angina pectoris, symptomatic congestive heart failure, myocardial

infarction ≤ 6 months prior to first study treatment

- Serious uncontrolled cardiac arrhythmia

- Severely impaired lung function

- Active (acute or chronic) or uncontrolled infection

- Non-malignant medical illness that is uncontrolled or that the control may be

jeopardized by the study therapy

- Liver disease (i. e., cirrhosis, chronic active hepatitis, chronic persistent


- No uncontrolled diabetes mellitus (i. e., fasting serum glucose > 1. 5 times ULN)

- No HIV seropositivity

- Not pregnant or nursing

- Fertile patients must use effective contraception

- No oral, implantable, or injectable contraceptives

- No impairment of gastrointestinal function or gastrointestinal disease that may

significantly alter the absorption of everolimus (e. g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection)

- No active, bleeding diathesis

- No known hypersensitivity to everolimus or other rapamycins (e. g., sirolimus,

temsirolimus) or to its excipients

- Must be able to take and retain oral medication

- No peripheral neuropathy > grade 1 as per NCI CTCAE vs. 3 NOTE: *In case one or both

of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid-lowering medication. PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- Recovered from prior therapy

- More than 3 weeks since prior and no concurrent investigational drugs

- At least 3 weeks since prior chemotherapy

- At least 2 weeks since prior major surgery or completion of radiotherapy

- No immunization with attenuated live vaccines within the past week or during study


- No prior treatment with an mTOR inhibitor (e. g., sirolimus, temsirolimus, or


- No chronic treatment with systemic steroids or other immunosuppressive agents

- No concurrent oral anti-vitamin K medication (except low dose coumadin)

- No concurrent medications interfering with everolimus

- No other concurrent anticancer agents

Locations and Contacts

University of California Davis Cancer Center, Sacramento, California 95817, United States
Additional Information

Starting date: January 2009
Last updated: July 22, 2011

Page last updated: August 23, 2015

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