Sevoflurane-Remifentanil Anaesthesia. The Risk of Post Operative Nausea
Information source: Viborg Hospital
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Nausea; Vomiting
Intervention: Sevoflurane-remifentanil anaesthesia (Procedure)
Phase: N/A
Status: Completed
Sponsored by: Viborg Hospital Official(s) and/or principal investigator(s):
Jens Ole Dich JO Nielsen, MD, Principal Investigator, Affiliation: Unaffiliated
Summary
The purpose of this study is to determine whether sevoflurane-remifentanil anaesthesia is
similar to propofol-remifentanil anaesthesia concerning post- operative nausea and vomiting.
Clinical Details
Official title: Postoperative Nausea and Vomiting Are Similar When Propofol or Sevoflurane Are Used as Adjuvant to Remifentanil During Anaesthesia for Gynaecological Surgery
Study design: Prevention, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study
Primary outcome: Nausea, incidence and intensity ( VAS score )in PACU and surgical wardVomiting, incidence in PACU and surgical ward Total PONV after 24 hours
Detailed description:
Propofol and sevoflurane anaesthesia are used world wide at the anaesthetists discretion.
Propofol is superior to inhalational anaesthetics as anaesthesia for patients at risk of post
operative nausea and vomiting (PONV) as PONV is diminished. However, when remifentanil is
used as adjuvant to sevoflurane, the total dose of the latter is reduced.
Therefore, we wanted to investigate if sevoflurane-remifentanil anaesthesia is similar to
propofol-remifentanil anaesthesia with emphasis on nausea, vomiting and total PONV during 24
hours.
In the post anaesthesia care unit (PACU) and in the surgical ward nausea was scored on a
visual analogue score. Vomiting was registered.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Females younger than 50 years
- ASA I-II
- Scheduled to gynaecological laparotomies or laparoscopies
Exclusion Criteria:
- Medication known to act anti-emetic
- ASA status greater than II
- Malignant hyperthermia
- Allergy to the drugs used.
Locations and Contacts
Viborg Hospital, Viborg 8800, Denmark
Additional Information
Starting date: January 2002
Ending date: May 2005
Last updated: March 28, 2007
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