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Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy

Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Ankyloglossia

Intervention: administration of propofol (Drug); administration of alfentanil (Drug); administration of rocuronium (Drug)

Phase: N/A

Status: Completed

Sponsored by: Yonsei University


Several methods have been demonstrated to improve intubating conditions during sevoflurane induction in children. These include opioids, propofol, and addition of neuromuscular blocking agents in pediatric patients. But the study about the comparison of these agents has been uncommon. Frenectomy is common procedure to treat ankyloglossia. It is a short procedure performed under general anesthesia. The investigators aimed to compare intubating conditions among children with propofol, alfentanil or rocuronium after sevoflurane induction.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator)

Primary outcome: Intubating condition


Minimum age: 1 Year. Maximum age: 9 Years. Gender(s): Both.


Inclusion Criteria:

- Children, 1-9 years old scheduled elective frenectomy under general anesthesia

Exclusion Criteria:

- Patients with an abnormal airway, reactive airway disease, gastroesophageal reflux

disease, chronic respiratory disease, or a history of an upper respiratory tract infection in the preceding 6-week period

Locations and Contacts

Severance hospital, Seoul, Korea, Republic of
Additional Information

Related publications:

Devys JM, Mourissoux G, Donnette FX, Plat R, Schauvliège F, Le Bigot P, Dureau P, Plaud B. Intubating conditions and adverse events during sevoflurane induction in infants. Br J Anaesth. 2011 Feb;106(2):225-9. doi: 10.1093/bja/aeq346. Epub 2010 Dec 8.

Starting date: February 2012
Last updated: February 4, 2014

Page last updated: August 23, 2015

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