Cross-Over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus
Information source: Case Western Reserve University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Nystagmus, Pathological
Intervention: gabapentin (Drug); memantine (Drug)
Phase: N/A
Status: Completed
Sponsored by: Case Western Reserve University
Summary
Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients,
who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV.
Two medicines have been reported to suppress nystagmus and improve vision in such patients:
gabapentin and memantine. The investigators set out to test which of these two drug was more
effective by carrying out a double-blind cross-over study. In this way, we could determine
which drug worked best in each patient.
Clinical Details
Official title: Investigation and Treatment of Ocular Motor Disorders: Cross-Over Comparison of Gabapentin and Memantine as Treatment for Nystagmus
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Visual acuity of each eye, measured during far or near viewingMedian eye speed during attempted visual fixation, of each eye.
Secondary outcome: Patient's report of whether they think that they have benefitted from either drug treatment
Detailed description:
The study entails careful measurements of visual acuity and precise measurements of eye
movements, using a contact lens device (magnetic search coil method). In this way, it is
possible to make objective and reliable measurements of the effect of each drug, which are
unbiased by the investigator or the patient.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Adult (18 years or older) males or females with acquired nystagmus that is degrading
their vision
Exclusion Criteria:
- Pregnant women
- Individuals who cannot described their visual symptoms, cooperate with testing, or
give informed consent
- Individuals with intolerance of gabapentin or memantine
Locations and Contacts
Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, Ohio 44106, United States
Additional Information
Starting date: February 2005
Last updated: June 25, 2009
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