The Comparison Between the Therapeutic Affect of Intravitreal Diclophenac and Triamcinolone in Persistent Uveitic Cystoids Macular Edema
Information source: Shahid Beheshti Medical University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Uveitis; Cystoid Macular Edema
Intervention: Diclophenac (Drug); Triamcinolone (Drug)
Phase: Phase 1
Status: Recruiting
Sponsored by: Shahid Beheshti Medical University
Summary
Cystoids macular edema (CME) is one of the most common causes of low vision due to uveitis.
The treatment for reducing the intra-ocular inflammation can decrease the macular edema. In
some patients, CME persists even after inflammation control, and additional treatment is
needed for better vision. Oral steroid, periocular and intravitreal Triamcinolone are the
principles in treatment, but some complications like cataracts and increased ocular pressure
have been seen. Diclophenac is a non-steroid anti-inflammatory drug that improves the vision
and decreases the macular thickness by slowing down the prostaglandin E2 (PGE2) ending in
vascular endothelial growth factor (VEGF) inhibition. In this study, the investigators are
going to compare the therapeutic affect of intravitreal Diclophenac and Triamcinolone in
persistent uveitic cystoids macular edema. Since diclophenac is a cheap and accessible drug
in all curative centers it could be applied instead of Triamcinolone.
Clinical Details
Official title: The Comparison Between the Therapeutic Affect of Intravitreal Diclophenac and Triamcinolone in Persistent Uveitic Cystoids Macular Edema
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- cystoids macular edema which is diagnosed by OCT and flurocein angiography
- 5/200 < Visual acuity < 20/50
- resistance to routine treatment (oral treatment, periocular injection)
Exclusion Criteria:
- history of retinal disease cause macular edema like diabetes
- arterial occlusion
- monocular patients
- patients candidate for intra-ocular operation
- history of glaucoma or ocular hypertension
- any cataract that would interfere with OCT
Locations and Contacts
Ophthalmic Research Center, Tehran 166666, Iran, Islamic Republic of; Recruiting Masoud Soheilian, MD, Phone: +98 21 22585952, Email: labbafi@hotmail.com
Additional Information
Last updated: May 4, 2009
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