DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Comparison of 7-Day and 14-Day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication

Information source: Asan Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Helicobacter Infection

Intervention: pantoprazole (Drug); bismuth (Drug); metronidazole (Drug); tetracycline (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Asan Medical Center

Official(s) and/or principal investigator(s):
Hwoon-Yong Jung, M.D, Principal Investigator, Affiliation: Asan Medical Center

Overall contact:
Jun-Won Chung, M.D., Phone: 82-2-3010-3188, Email: junwonchung@hanmail.net

Summary

At present, triple therapy are recommended by various guidelines for the treatment of Helicobacter pylori (H. pylori) infection. Recent studies have shown worldwide high treatment failure rates with one week first line clarithromycin based triple therapy necessitating salvage strategy to eradicate H. pylori in primary treatment failure. However, the exact duration of bismuth based second line treatment is not determined. Therefore, the investigators performed this study to evaluate the eradication rate of 1 or 2-week quadruple regimen as a second-line therapy.

Clinical Details

Official title: Comparison of 7-Day and 14-Day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication.

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Whether the two week group yield a higher eradication rate comparing to the one week group.

Secondary outcome: side effect

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- H. pylori infection

- Aged between 18-80 years

- Are willing to received eradication therapy for H. pylori

Exclusion Criteria:

- Children and teenagers aged less than 18 years or over 80 years

- Previous eradication therapy for H. pylori

- History of gastrectomy

- Previous allergic reaction to antibiotics

- Use of prompt pump inhibitors and antibiotics in the recent 4 weeks

- Active upper GI bleeding in the recent 1 week

- Contraindication to treatment drugs

- Pregnant or lactating women

- Severe concurrent disease or malignancy

Locations and Contacts

Jun-Won Chung, M.D., Phone: 82-2-3010-3188, Email: junwonchung@hanmail.net

Asan Medical Center, Seoul 138-736, Korea, Republic of; Recruiting
Jun-Won Chung, M.D., Phone: 82-2-3010-3188, Email: junwonchung@hanmail.net
Additional Information

Starting date: June 2008
Last updated: February 10, 2009

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017