Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers
Information source: Oslo University Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Acute Pain; Respiration; Sedation
Intervention: Remifentanil+clonidine (Drug)
Phase: Phase 1/Phase 2
Status: Completed
Sponsored by: Oslo University Hospital Official(s) and/or principal investigator(s): Jon B Bergmann, Ass. Prof., Principal Investigator, Affiliation: Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center
Summary
The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to
relief acute main in an experimental human pain model. Of interest is also the effect of the
combination on respiration, sedation and cognitive behavior.
Clinical Details
Official title: Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Relief of pain(VAS reduction)
Secondary outcome: Reduction in Minute ventilationReduction in CO2 stimulated Minute Ventilation Reduction in BIS score Performance on Stroop test
Detailed description:
To examine the possible synergistic effects og systemic remifentanil and clonidine. Its
effects on respiration, cognitive function and sedation.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Healthy volunteers
Exclusion Criteria:
-
Locations and Contacts
Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center, Oslo 0027, Norway
Additional Information
Starting date: February 2005
Last updated: July 3, 2011
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