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Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers

Information source: Oslo University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acute Pain; Respiration; Sedation

Intervention: Remifentanil+clonidine (Drug)

Phase: Phase 1/Phase 2

Status: Completed

Sponsored by: Oslo University Hospital

Official(s) and/or principal investigator(s):
Jon B Bergmann, Ass. Prof., Principal Investigator, Affiliation: Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center

Summary

The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.

Clinical Details

Official title: Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: Relief of pain(VAS reduction)

Secondary outcome:

Reduction in Minute ventilation

Reduction in CO2 stimulated Minute Ventilation

Reduction in BIS score

Performance on Stroop test

Detailed description: To examine the possible synergistic effects og systemic remifentanil and clonidine. Its effects on respiration, cognitive function and sedation.

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Healthy volunteers

Exclusion Criteria:

-

Locations and Contacts

Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center, Oslo 0027, Norway
Additional Information

Starting date: February 2005
Last updated: July 3, 2011

Page last updated: August 23, 2015

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