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Isoflurane at Subanesthetic Concentrations - 6

Information source: University of Chicago
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Opioid-Related Disorders; Substance-Related Disorders

Intervention: 40% Nitrous oxide (Drug); Sham comparator (Other); 0.2% isoflurane (Drug); 0.4% isoflurane (Drug); 0.6% isoflurane (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: University of Chicago

Official(s) and/or principal investigator(s):
James Zacny, Ph.D., Principal Investigator, Affiliation: University of Chicago


The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.

Clinical Details

Official title: Isoflurane at Subanesthetic Concentrations

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: Pain response


Minimum age: 21 Years. Maximum age: 34 Years. Gender(s): Male.


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Locations and Contacts

University of Chicago, Anesthesia & Critical Care, Chicago, Illinois 60637, United States
Additional Information

Related publications:

Anesthesiology, 1995, 83: A287

Starting date: January 1995
Last updated: May 26, 2015

Page last updated: August 23, 2015

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