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The Effect of Antihypertensive Agents Concerning With Hemodynamics and Reduction of Anaesthetics in Orthognathic Surgery

Information source: Yonsei University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Orthognathic Surgery

Intervention: b-blocker(Atenolol) (Drug); ACE inhibitor(Enapril) (Drug); control (Other)

Phase: N/A

Status: Completed

Sponsored by: Yonsei University


For those who receive hypotensive anesthesia in orthognathic surgeries, the investigators premedicate with anti-hypertensive agent so that it decreases the occurence of tachycardia and the rebound hypertension due to hypotensive anesthesia, enabling us to compare hemodynamic stability and reduction of anesthetic agents during the operation.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Supportive Care

Primary outcome: the influence of antihypertensive agents on hemodynamic stability

Secondary outcome: reduction of anaesthetics with control


Minimum age: 18 Years. Maximum age: 29 Years. Gender(s): Both.


Inclusion Criteria: 1. ASA class I-II 2. obtaining written informed consent from the parents 3. aged 18-29 years who were undergoing orthognathic surgery. Exclusion Criteria: 1. Hypertension patients with anti-hypertensive agents 2. chronic renal failure or End stage renal disease patients. 3. renal artery stenosis history. 4. Patients who are with medication due to systemic disease. 5. symptomatic asthma 6. Drug hyperactivity 7. neurological or psychiatric illnesses 8. mental retardation 9. patients who can`t read the consent form due to illiterate or foreigner

Locations and Contacts

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea, Republic of
Additional Information

Starting date: August 2012
Last updated: March 31, 2014

Page last updated: August 23, 2015

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