T3 Versus T4 Sympathicotomy for Treatment of Primary Palmar Hyperhidrosis
Information source: Mansoura University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Compensatory Hyperhidrosis; Recurrence
Intervention: t3 sympathicotomy (Procedure); t4 symapthicotomy (Procedure)
Phase: N/A
Status: Completed
Sponsored by: Mansoura University Official(s) and/or principal investigator(s): ahmed negm, md, Principal Investigator, Affiliation: mansoura university hospital
Summary
T3 versus T4 as a primary treatment for palmer hyperhydrosis and effect on postoperative
compensatory hyperhydrosis
Clinical Details
Official title: T3 Versus T4 Sympathicotomy for Treatment of Primary Palmar Hyperhidrosis: a Prospective Randomized Study
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Primary outcome: postoperative compensatory hyperhidrosis
Secondary outcome: improvement of planter sweating assessment of overdry hands early postoperative complication ( pneumothorax,,,,,) recurrance
Detailed description:
Palmar hyperhidrosis (PH) is a benign sympathetic disorder that does not threaten health but
affects daily activities, and may causes social withdrawal and even depression. 1 An
incidence of up to 1% has been reported by various series in the literature. The incidence
in men and women is the same; however women are more likely to seek medical attention, which
may explain the higher incidence of female patients in most surgical series [2,3]. Although
various treatment options are available, including topical and systemic therapies,
iontophoresis, regional nerve block, and botulinum toxin injection, each has its limitations
4. Video-assisted thoracoscopic sympathetic surgery is currently a worldwide accepted
treatment of primary palmar hyperhidrosis (PH) 5. However, compensatory hyperhidrosis (CH)
is the most common and serious side effect that occurs in 30-70% of patients after T2 or
T2-3 sympathectomy 6. For that now T2 sympathetic surgeries are seldom used in PH.
Procedures that involve T3 or/and T4 sympathetic ganglions are widely accepted in many
centers with favourable results. 5 But some patients still present with certain degrees of CH
or over dry hands after operation 7, 8.
The aim of this study is to compare the two methods for the treatment of PH, in which the
sympathetic chain was transected in merely one segment, on the level of either the third or
the fourth ribbed, defined as T3 sympathicotomy or T4 sympathicotomy, respectively. Emphasis
was placed on the evaluation of the efficacy, side effects, and patients' satisfaction rate
to these two types of surgical therapy.
Eligibility
Minimum age: 15 Years.
Maximum age: 38 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients with primary palmar hyperhidrosis
Exclusion Criteria:
- Patients with pleural adhesion
- Bleeding diathesis
- Local infection
- Patients with certain anatomic anomalies
Locations and Contacts
Mansoura University Hospital, Mansoura 35111, Egypt
Additional Information
Related publications: Chou SH, Kao EL, Lin CC, Chang YT, Huang MF. The importance of classification in sympathetic surgery and a proposed mechanism for compensatory hyperhidrosis: experience with 464 cases. Surg Endosc. 2006 Nov;20(11):1749-53. Epub 2006 Oct 5.
Starting date: February 2008
Last updated: February 14, 2011
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