Guanfacine for the Treatment of Spatial Neglect and Impaired Vigilance
Information source: Imperial College London
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Stroke; Hemispatial Neglect
Intervention: Guanfacine (Drug); Placebo (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Imperial College London Official(s) and/or principal investigator(s): Paresh A Malhotra, PhD MRCP, Principal Investigator, Affiliation: Imperial College London Masud Husain, DPhil FRCP, Principal Investigator, Affiliation: University College, London
Summary
To find out if spatial neglect following stroke and brain injury can be reduced using
guanfacine, a drug that was shown to improve neglect in two stroke patients in a previous
pilot study (Malhotra et al, 2006). In this trial, the effects of guanfacine will be
examined in a larger number of patients, and there will also be a systematic assessment of
whether the drug is only effective in patients with particular patterns of brain damage.
Clinical Details
Official title: A Trial of Guanfacine, an Alpha 2 Adrenergic Agonist, for Spatial Neglect and Impaired Vigilance Following Stroke and Focal Brain Damage
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Primary outcome: Performance on tests of hemispatial neglect and sustained attention
Secondary outcome: Performance on Motor Tasks
Detailed description:
The current study has a double-blind crossover design where patients will receive a single
2mg dose of oral guanfacine and a single dose of placebo. They will receive one of these on
Day 2 of the study period and the other on Day 4.
They will be tested daily on Days 1 to 5 so that any test repetition or long-term drug
effects can be gauged.
On days 2 and 4 they will be tested twice-once prior to drug/placebo administration and
again 90 minutes after drug/placebo administration.
Tests will include standard pen-and-paper tasks for neglect as well as computerised tests of
sustained attention and visual exploration. In our published pilot study (Malhotra et al,
2006) there was a suggestion that patients without damage to frontal cortex were more likely
to respond to guanfacine. In the current study we intend to test 10 patients with and 10
patients without frontal damage in order to test this further.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age 18 or more
- Greater than 2 weeks following stroke
- Ability to give consent
- Evidence of robust Visual Neglect when tested twice with cancellation tasks.
Exclusion Criteria:
- Less than 2 weeks following stroke
- Concomitant illness that may affect interpretation of any findings
- Labile blood pressure following stroke
- Systolic BP less than 100 mmHg and / or diastolic less than 70 mmHg
- New antihypertensive medication started within last 3 weeks
- Patients with hepatic or renal dysfunction
- Patients receiving other medications known to potentiate guanfacine's
antihypertensive and hypotensive effects or cause torsade de pointes, specifically
antipsychotics (including sultopride, chlorpromazine, thioridazine, amisulpiride,
sulpiride, haloperidol), and moxifloxacin, baclofen, verapamil, quinidine,
hydroquinidine, dispyramide, amiodarone, dofetilide, ibutilide, sotalol, pimozide,
bepridil, cisapride, diphemanil, erythromycin IV, halofantrine, pentamidine,
sparfloxacin, vincamine, alfuzosin, prazosin, terazosin, tamsulosin, amifostine
- Patients with diagnosis of brain tumour
- Patients with weight less than 55kg
- Patients who are pregnant
- Mothers who are breast feeding
- Patients with severe coronary insufficiency or myocardial infarction in previous 6
months
- Cognitive impairment, dysphasia or dementia that prevents patient from giving
informed consent
- Severe mental impairment or physical handicap following stroke that prevents patients
from giving consent or performing basic (standard clinical) tests for neglect
Locations and Contacts
Imperial College Healthcare NHS Trust, London W6 8RF, United Kingdom
Additional Information
Related publications: Malhotra PA, Parton AD, Greenwood R, Husain M. Noradrenergic modulation of space exploration in visual neglect. Ann Neurol. 2006 Jan;59(1):186-90.
Starting date: April 2010
Last updated: June 3, 2015
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