DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more


Nutrilib.com
A comprihensive source of nutritional information

The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior

Information source: Yale University
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Smoking Lapse Behavior

Intervention: varenicline (Drug); bupropion (Drug); Placebo (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Yale University

Official(s) and/or principal investigator(s):
Sherry A McKee, PhD, Principal Investigator, Affiliation: Yale University

Overall contact:
Sabrina Coppola, Phone: 203-737-2827

Summary

The purpose of this study is to examine how smoking cessation medications (varenicline, bupropion) affect the ability to resist smoking and also subsequent ad-lib smoking in non-treatment seeking daily smokers.

Clinical Details

Official title: The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior

Study design: Treatment, Randomized, Double Blind (Subject, Investigator, Outcomes Assessor), Factorial Assignment

Primary outcome: latency to initiate ad-lib smoking session

Secondary outcome: number of cigarettes smoked during the ad-lib period

Eligibility

Minimum age: 21 Years. Maximum age: 55 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- ages 18-55

- able to read and write in English

- Smokers

Exclusion Criteria:

- any significant current medical or psychiatric conditions that would contraindicate

smoking

- current DSM-IV abuse or dependence of other substances, other than nicotine dependence

or alcohol abuse

- positive test result at intake appointments on urine drug screens conducted for

opiates, cocaine, or benzodiazepines

- women who are pregnant or nursing

- suicidal, homicidal, or evidence of current severe mental illness

- participants prescribed any psychotropic drug in the 30 days prior to study

enrollment

- blood donation within the past 6 weeks

- individuals seeking treatment for smoking cessation or have attempted to quit smoking

within the past 3 months

- specific exclusions for bupropion administration not already specified, including:

have taken monoamine inhibitors in the past 6 weeks; history of anorexia or bulimia; previous hypersensitivity to bupropion; history of alcohol or drug dependence in the past year; history of seizure disorder of any etiology

- known allergy to varenicline or taking H2blockers

- participation within the past 8 weeks in other studies that involve additive blood

sampling and/or interventional measures that would be considered excessive in combination with the current study

Locations and Contacts

Sabrina Coppola, Phone: 203-737-2827

Yale Center for Clinical Investigation, Yale University, New Haven, Connecticut 06519, United States; Recruiting
Additional Information

Starting date: April 2007
Ending date: August 2009
Last updated: October 14, 2008

Page last updated: November 03, 2008

-- advertisement -- The American Red Cross

We comply with
HONcode standard.
Verify here.
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2008