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Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-Secretion Caused by Treatment With Antiepileptic Medicine

Information source: Regional Hospital Holstebro
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Syndrome of Inappropriate ADH-Secretion

Intervention: fluid restriction for 14 days (15ml fluid per kg weight) (Procedure)

Phase: Phase 4

Status: Withdrawn

Sponsored by: Regional Hospital Holstebro

Official(s) and/or principal investigator(s):
Erling B Pedersen, Professor, Study Chair, Affiliation: Holstebro Hospital, Denmark

Summary

Patients treated with the antiepileptic drug Oxcarbazepine often develop syndrome of inappropriate secretion of antidiuretic hormone(SIADH)We want to test the hypothesis, that these patients have a higher reabsorption of water during the Aquaporine2 water channels,a higher concentration of Vasopressine (AVP), and a lower clearance of water. This situation will tend to normalize, when the patients are treated with fluid restriction

Clinical Details

Official title: Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-Secretion Caused by Treatment With Antiepileptic Medicine

Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Detailed description: The purpose of the study is to determine the amount of Aquaporine2(AQP2)in the urine in patients treated with the antiepileptic drug Oxcarbazepine before and after the administration of fluid restriction

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: Age more than 18 years, both men and women, patients with epilepsia treated with Oxcarbazepine, and a Sodium content in plasma lower than 130 mmol/liter Exclusion Criteria: severe diseases in the heart, lungs or liver;diabetes mellitus, other not-well treated diseases in endocrine organs, cancer; unwillingness to participate

Locations and Contacts

Department of Medicine, Holstebro Hospital, Holstebro, Jutland 7500, Denmark
Additional Information

Starting date: May 2005
Last updated: July 11, 2007

Page last updated: August 23, 2015

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