Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-Secretion Caused by Treatment With Antiepileptic Medicine
Information source: Holstebro Hospital
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Syndrome of Inappropriate ADH-Secretion
Intervention: fluid restriction for 14 days (15ml fluid per kg weight) (Procedure)
Phase: Phase 4
Status: Withdrawn
Sponsored by: Holstebro Hospital Official(s) and/or principal investigator(s):
Erling B Pedersen, Professor, Study Chair, Affiliation: Holstebro Hospital, Denmark
Summary
Patients treated with the antiepileptic drug Oxcarbazepine often develop syndrome of
inappropriate secretion of antidiuretic hormone(SIADH)We want to test the hypothesis, that
these patients have a higher reabsorption of water during the Aquaporine2 water channels,a
higher concentration of Vasopressine (AVP), and a lower clearance of water. This situation
will tend to normalize, when the patients are treated with fluid restriction
Clinical Details
Official title: Urinary Aquaporine 2 in Patients With Syndrome of Inappropriate ADH-Secretion Caused by Treatment With Antiepileptic Medicine
Study design: Non-Randomized, Open Label, Placebo Control, Parallel Assignment
Detailed description:
The purpose of the study is to determine the amount of Aquaporine2(AQP2)in the urine in
patients treated with the antiepileptic drug Oxcarbazepine before and after the
administration of fluid restriction
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
Age more than 18 years, both men and women, patients with epilepsia treated with
Oxcarbazepine, and a Sodium content in plasma lower than 130 mmol/liter
Exclusion Criteria:
severe diseases in the heart, lungs or liver;diabetes mellitus, other not-well treated
diseases in endocrine organs, cancer; unwillingness to participate
Locations and Contacts
Department of Medicine, Holstebro Hospital, Holstebro, Jutland 7500, Denmark
Additional Information
Starting date: May 2005
Last updated: July 11, 2007
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