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Ondansetron for the Treatment of Methamphetamine Dependence - 1

Information source: National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Amphetamine-Related Disorders

Intervention: Ondansetron (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: National Institute on Drug Abuse (NIDA)

Official(s) and/or principal investigator(s):
Thomas Newton, M.D., Principal Investigator, Affiliation: National Institute on Drug Abuse (NIDA)


The purpose of this study is to assess ondansetron for the treatment of methamphetamine dependence.

Clinical Details

Official title: Double-Blind, Placebo-Controlled, Dose Response Trial of Ondansetron for the Treatment of Methamphetamine Dependence.

Study design: Allocation: Randomized, Masking: Double-Blind, Primary Purpose: Treatment

Primary outcome: Clinicial improvement

Detailed description: This study was designed to be a preliminary assessment of the efficacy and safety of 3-wide range doses of ondansetron (0. 25, 1. 0 and 4. 0 mg taken orally twice per day) to reduce methamphetamine use in subjects with methamphetamine dependence and to determine the optimal dose of ondansetron.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria: 18 years of age. Treatment seeking for meth dependence. Exclusion Criteria: Please contact site director for more details.

Locations and Contacts

South Bay Treatment Center, Chula Vista, California 91911, United States

Matrix Institute on Addictions, Costa Mesa, California 92627, United States

John A. Burns School of Medicine, Honolulu, Hawaii 96813, United States

Powell Chemical Dependency Center, Des Moines, Iowa 50316, United States

University of Missouri - Kansas City, Kansas City, Missouri 64108, United States

University of Texas Health Science Center, Houston, Texas 77225, United States

Additional Information

Starting date: June 2002
Last updated: July 21, 2008

Page last updated: August 20, 2015

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