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A Compassionate Use Study of Tenofovir Disoproxil Fumarate as Treatment for HIV Infection

Information source: NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: HIV Infections

Intervention: Tenofovir disoproxil fumarate (Drug)

Phase: N/A

Status: Completed

Sponsored by: Gilead Sciences

Summary

This study allows patients who need a new anti-HIV treatment to take tenofovir disoproxil fumarate (tenofovir DF), an experimental drug. This study also looks at any side effects the drug causes.

Clinical Details

Official title: An Open-Label, Multicenter, Compassionate Access Study of the Safety of Tenofovir Disoproxil Fumarate Administered in Combination With Other Antiretroviral Agents for the Treatment of HIV-1 Infected Patients

Study design: Primary Purpose: Treatment

Detailed description: HIV-1-infected patients who are currently receiving stable antiretroviral therapy add tenofovir DF to their regimen. Study participation lasts for approximately 48 weeks. Interested patients should contact their physicians.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria You may be eligible for this study if you:

- Are HIV-positive.

- Have a viral load greater than or equal to 10,000 copies/ml.

- Have a CD4 count less than or equal to 50 cells/mm3, or have a CD4 count greater than

50 and no more than 200 cells/mm3 with an opportunistic (AIDS-related) infection within 90 days of study entry. (Patients with a CD4 count above 200 cells/mm3 may be considered depending on drug supply.)

- Are at least 18 years old.

- Agree to use barrier methods of birth control (such as condoms) while on the study

and for 30 days afterward.

- Have a life expectancy of at least one year.

Exclusion Criteria You will not be eligible for this study if you:

- Have a history of a serious kidney or bone disease.

- Have severe nausea, vomiting, or trouble taking medications by mouth.

- Are pregnant or breast-feeding.

- Abuse alcohol or other substances that your doctor thinks would interfere with taking

this medicine.

- Are taking any medicines that interfere with kidney functions.

Locations and Contacts

Tenofovir Coordinating Center, Foster City, California 94404, United States
Additional Information

Starting date: December 1999
Last updated: June 23, 2005

Page last updated: August 23, 2015

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