DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Treatment of Hypertension in Tibetan Adult Population

Information source: West China Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertension

Intervention: Nitrendipine (Drug); Hydrochlorothiazide (Drug); Captopril,Hydrochlorothiazide (Drug); Beijing hypotensive No.0 (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: West China Hospital

Official(s) and/or principal investigator(s):
Xiaoping Chen, MD, Principal Investigator, Affiliation: West China Hospital

Overall contact:
Xiaoping Chen, MD, Phone: 86-028-85422175, Email: xiaopingchen11@126.com

Summary

Several surveys had revealed that Tibetan adults had high prevalence of hypertension. However, there was no research studying the antihypertensive effect of the known drugs in Tibetan. The main arms of our study were to determine if the efficacy of lowing blood pressure and protecting target organ damage differs between nitrendipine and Hydrochlorothiazide in mild hypertension in Tibetan, and to determine if the efficacy of lowing blood pressure and protecting target organ damage differs between captopril plus Hydrochlorothiazide and Beijing hypotensive No. 0 in moderate and severe Tibetan hypertension.

Clinical Details

Official title: A Randomized, Open-label, Positive Drug Controlled Clinical Trials to Compare the Efficacy of Nitrendipine and Hydrochlorothiazide , Captopril Plus Hydrochlorothiazide and Beijing Hypotensive No.0 in Tibetan Hypertension

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Change of Blood Pressure

Secondary outcome: Change of target organ damage

Detailed description: Several surveys had revealed that Tibetan adults had high blood pressure(BP)and prevalence of hypertension than other parts of China and were also higher than those in developed nations as well. For example, one study found that among Tibetan herdsmen 40 years and older, the prevalence of hypertension was 56% and the mean systolic blood pressure/diastolic blood pressure was 146. 6/92. 0mmHg. However, the rates of awareness, treatment, and control were dismally low. The Tibetan have been living in the Tibetan Plateau. The special natural and social environment there,as well as ethnic ,may all be involved in the etiology of the high prevalence and effect the response to antihypertensive treatment. Nevertheless, few interventional studies have been done in Tibetan hypertensive patients. Therefore, the purpose of our study was to compare the blood pressure reduction between different antihypertensive drugs. Nitrendipine, hydrochlorothiazide, captopril and Beijing hypotensive No. 0 (also named" compound hypotensive tablet") are selected, which are cheap and available in the Tibetan Plateau. Nitrendipine, hydrochlorothiazide and captopril are the representatives of Dihydropyridines Calcium antagonists, diuretics, and angiotensin-converting enzyme inhibitors, respectively. They are all recommended as the first-line antihypertensive drug. Beijing hypotensive No. 0 is produce by China Resources Double-crane Pharmaceutical company in China, and it is a fixed-dose combination containing reserpine 0. 1mg, hydrochlorothiazide 12. 5mg, dihydralazine sulfate 12. 5mg, triamterene 12. 5mg. Many studies conducted in China have demonstrated its efficacy and safety in lowing blood pressure. After recruitment, participant will be grouped according to their BP. If BP<160/100mmHg, monotherapy is started. Patient is randomly assigned to receive nitrendipine 10mg bid or Hydrochlorothiazide 12. 5mg qd. If BP≥160/100mmHg, Patient is randomly assigned to receive two drug combination therapy(captopril 25mg three times daily (tid) and Hydrochlorothiazide 12. 5mg qd) or Beijing hypotensive No. 0 one pile qd. During the following 12 months,each participant will take at least four visits at 1、3、6 and 12 months respectively. Goal BP for all participants was less than 140/90mmHg, achieved by titrating the assigned study drug and adding open-label agents when necessary. The maximum dosage is 20mg BID for nitrendipine, 25mg qd for Hydrochlorothiazide and 50mg tid for captopril. The dosage of Beijing hypotensive No. 0 should not be added.

Eligibility

Minimum age: 18 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Adult Tibetan, who have been living in the Tibetan Plateau since he/she was born. 2. Consistent with diagnosed hypertension, blood pressure, for 1-3 grade. 3. Aged 18-80 years old. 4. To sign informed consent. Exclusion Criteria: 1. diagnosis of secondary hypertension 2. Hypertensive emergencies and urgencies 3. Malignant hypertension 4. Bilateral renal artery stenosis, Chronic Kidney Disease(CKD), serum creatinine> 133μmol / L. 5. Suffering from congenital heart disease, rheumatic heart disease, hypertrophic cardiomyopathy, aortic stenosis. 6. Occurred within the past 6 months who had a stroke or transient ischemic attack (TIA), unstable angina, myocardial infarction, percutaneous transluminal coronary angioplasty (PTCA). 7. clinical significance of arrhythmia 8. Active liver disease, history of chronic persistent hepatitis, alanine aminotransferase(ALT)> upper limit of normal. 9. Pregnancy, pregnancy or breast-feeding women to prepare.

Locations and Contacts

Xiaoping Chen, MD, Phone: 86-028-85422175, Email: xiaopingchen11@126.com

West China Hospital, Chengdu, Sichuan 610041, China; Not yet recruiting
Additional Information

Starting date: August 2014
Last updated: August 28, 2014

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017