Capsaicinoid Ingestion, Human Metabolism and Exercise
Information source: University of Prince Edward Island
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Metabolism
Intervention: Capsaicin (Dietary Supplement)
Phase: Phase 1
Status: Recruiting
Sponsored by: University of Prince Edward Island Overall contact: Jamie F Burr, PhD, Phone: (902)620-5225, Email: jburr@upei.ca
Summary
Capsaicinoids (the active ingredient in hot peppers) have been shown to cause a moderate
increase in energy expenditure (50 kcal/day) as well as reductions in appetite, energy
intake, and (visceral) adiposity. As such, there is considerable interest in capsaicinoid
for weight loss supplements. Of particular interest are the recent findings that free-fatty
acids in the blood are elevated 2-2. 5hrs post ingestion, yet changes in typical
cardiovascular or sympathetic nervous tone indicators (heart rate, blood pressure) were
unaffected, suggesting some of the negative consequences of other stimulants may be avoided.
At present, however, more in depth investigations of the effects on endothelial function,
vascular autonomic tone and inflammation are lacking.
The investigators seek to understand the effect of 3 months capsaicinoid ingestion on
alterations in body composition, traditional cardiovascular risk factors and cardiovascular
function
Hypotheses:
1) Continued use of capsaicinoids will alter resting metabolism substrate use, which will
result in moderate (but clinically meaningful) alterations in body composition manifested as
a decrease in adiposity. 2) Blood lipids will be unaffected by capsaicinoid use, as will
brachial blood pressure. 3) Levels of systemic inflammation may increase slightly, and this
could have an effect on vascular reactivity to hyperemic flow or baseline vascular tone.
However, previous research suggests that these alterations will not be manifested in
autonomic nervous tone assessed by changes in heart rate variability.
Clinical Details
Official title: The Physiological Effects of Capsaicinoid Ingestion on Human Metabolism and Exercise Performance
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Energy substrate use (Fat vs Carbohydrate contributions to metabolism)
Secondary outcome: Cardiovascular risk factors
Eligibility
Minimum age: 18 Years.
Maximum age: 45 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Subjects will be male or female
- 18 yr -45yr and free from any known or suspected chronic conditions.
- General health and suitability to participate in an exercise/health research study
will be confirmed through use of the PAR-Q+ screening questionnaire
Exclusion Criteria:
- Any participant who has a positive answer to a screening question will be required to
seek physician approval prior to any physical exercise.
- Baseline arrhythmia (tachycardia (>100pbm) and systolic or diastolic hypertension
(>140/90 mmHg) will also be reason for exclusion.
- During baseline anthropometric assessment we will confirm that participants all fall
within a typical BMI range (20-30 kg/m2) of either "normal" weight or "overweight",
but not "underweight" or "obese".
- Persons who take cardiovascular medications, metabolic medications, smoke cigarettes,
excessively consume alcohol, are prone to heartburn, or have a previous diagnosis of
hyperlipidemia or hyperinsulemia will also be excluded
Locations and Contacts
Jamie F Burr, PhD, Phone: (902)620-5225, Email: jburr@upei.ca
UPEI, Charlottetown, Prince Edward Island C1A4P3, Canada; Recruiting Jamie F Burr, PhD, Phone: (902)620-5225, Email: jburr@upei.ca Jamie F Burr, PhD, Principal Investigator
Additional Information
Starting date: June 2014
Last updated: June 6, 2014
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