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Effect of Alphagan and Xalatan Eye Drops on Corneal Temperature

Information source: University Hospital, Basel, Switzerland
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Primary Vascular Dysregulation

Intervention: Brimonidine (Drug); Latanoprost (Drug); Placebo (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: University Hospital, Basel, Switzerland

Official(s) and/or principal investigator(s):
Josef Flammer, MD, Study Director, Affiliation: University of Basel, Dept. of Ophthalmology

Overall contact:
Katarzyna Konieczka, MD, Phone: +41 61 265 8803, Email: kkonieczka@uhbs.ch

Summary

It is already known that the local treatment with Alphagan eye drops (a drug commonly used by glaucoma patients) reduces ocular blood flow. In-vitro studies suggest that the vasoconstrictive effect of Alphagan is more pronounced when this drug is combined with a prostaglandin analogue (eg. Xalatan eye drops). The investigators also question whether this effect is more pronounced in subjects suffering from a primary vascular dysregulation (PVD). To test for the effect of these drugs on PVD and non-PVD subjects the investigators will take measurements of corneal temperature as surrogate for ocular blood flow.

Clinical Details

Official title: Effect of Alphagan and Xalatan Eye Drops on Corneal Temperature

Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: Corneal temperature

Secondary outcome:

Intraocular pressure

Ear temperature

Blood pressure

Detailed description: The investigators would like to investigate the effect of Alphagan eye drops, Xalatan eye drops and their combination (both Alphagan and Xalatan) on corneal temperature in healthy subjects with and without a primary vascular dysregulation (PVD).

The investigators would like to answer the following questions:

1. Do the individual drugs influence the circulation to the eye as quantified indirectly via corneal temperature?

2. Does the combination of Alphagan and Xalatan give an additive or even potentiated effect?

3. Is the sequence of application of drugs of relevance (Alphagan applied first, Xalatan second, or vice versa)?

4. Do PVD and non-PVD subjects respond differently to these drugs?

20 healthy non-PVD subjects and 20 healthy PVD subjects in the age range from 20-40 years will be recruited. Recruited subjects will have all measurements: corneal temperature, intraocular pressure (IOP), ear temperature, blood-pressure. Both prior to and after instillation of eye drops (Xalatan, Alphagan and placebo).

Eligibility

Minimum age: 20 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- healthy

- age 20-50 years

- normal findings on ophthalmological examination

Exclusion Criteria:

- history of ocular or systemic disease

- chronic or current systemic or topical medication

- drug or alcohol abuse

- art. hypertension

Locations and Contacts

Katarzyna Konieczka, MD, Phone: +41 61 265 8803, Email: kkonieczka@uhbs.ch

University of Basel, Dept. of Ophthalmology, Basel 4031, Switzerland; Recruiting
Maneli Mozaffarieh, MD, Phone: +41 61 265 8807, Email: mmozaffarieh@uhbs.ch
Additional Information

Starting date: June 2011
Last updated: August 24, 2012

Page last updated: February 07, 2013

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