Treat Clozapine ( CLZ )-Resistant Schizophrenia Comparing CLZ + Haloperidol vs. CLZ + Electroconvulsive Therapy (ECT)
Information source: Khon Kaen University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Schizophrenia
Intervention: clozapine+haloperidol (Drug); clozapine,electroconvulsive therapy (Drug)
Phase: N/A
Status: Completed
Sponsored by: Khon Kaen University Official(s) and/or principal investigator(s): Suchat Paholpak, MD, Principal Investigator, Affiliation: Department of Psychiatry.Faculty of Medicine.Khon Kaen University
Summary
Clozapine treatment resistant schizophrenia is still prevalent. The effectiveness of
augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive
therapy should be determined. This study is a randomized control trial.
Clinical Details
Official title: Treatment of Clozapine-resistant Schizophrenia : Comparison Between Augmentation With Haloperidol and Electroconvulsive Therapy
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: PANSS , HAM-D , CGI , AIMS Scores
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
1. schizophrenic patients diagnosed with schedules for clinical assessment in
neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10
2. Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage
3. Voluntary to participate the research protocol expressed by signing informed consent
form
Exclusion Criteria:
1. Patient does not volunteer himself or herself
2. Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate
3. Patient is deaf, blind , dumb to obstruct good communication
Locations and Contacts
Department of Psychiatry.Faculty of Medicine.KhonKaen University., Muang, KhonKaen 40002, Thailand
Additional Information
Starting date: June 2008
Last updated: May 4, 2012
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