Treat Clozapine-Resistant Schizophrenia Comparing Between Clozapine + Haloperidol Versus Clozapine + Electroconvulsive Therapy (ECT)
Information source: Khon Kaen University
Information obtained from ClinicalTrials.gov on December 08, 2011
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Schizophrenia
Intervention: clozapine+haloperidol (Drug); clozapine,electroconvulsive therapy (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Khon Kaen University Official(s) and/or principal investigator(s):
Suchat Paholpak, MD, Principal Investigator, Affiliation: Department of Psychiatry.Faculty of Medicine.Khon Kaen University
Overall contact:
Suchat Paholpak, MD, Phone: 66-81-6610674, Email: suchat_p@kku.ac.th
Summary
Clozapine treatment resistant schizophrenia is still prevalent. The effectiveness of
augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive
therapy should be determined. This study is a randomized control trial.
Clinical Details
Official title: Treatment of Clozapine-Resistant Schizophrenia : Comparison Between Augmentation With Haloperidol and Electroconvulsive Therapy
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: PANSS , HAM-D , CGI , AIMS Scores
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
1. schizophrenic patients diagnosed with schedules for clinical assessment in
neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10
2. Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage
3. Voluntary to participate the research protocol expressed by signing informed consent
form
Exclusion Criteria:
1. Patient does not volunteer himself or herself
2. Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate
3. Patient is deaf, blind , dumb to obstruct good communication
Locations and Contacts
Suchat Paholpak, MD, Phone: 66-81-6610674, Email: suchat_p@kku.ac.th
Department of Psychiatry.Faculty of Medicine.KhonKaen University., Muang, KhonKaen 40002, Thailand; Recruiting
Suchat Paholpak, Phone: 66-81-6610674, Email: suchat_p@kku.ac.th
Suchat Paholpak, MD, Phone: 66-81-6610674, Email: suchat_p@kku.ac.th
Suchat Paholpak, MD, Principal Investigator
Additional Information
Starting date: June 2008
Last updated: September 15, 2008
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