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Treat Clozapine ( CLZ )-Resistant Schizophrenia Comparing CLZ + Haloperidol vs. CLZ + Electroconvulsive Therapy (ECT)

Information source: Khon Kaen University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Schizophrenia

Intervention: clozapine+haloperidol (Drug); clozapine,electroconvulsive therapy (Drug)

Phase: N/A

Status: Completed

Sponsored by: Khon Kaen University

Official(s) and/or principal investigator(s):
Suchat Paholpak, MD, Principal Investigator, Affiliation: Department of Psychiatry.Faculty of Medicine.Khon Kaen University


Clozapine treatment resistant schizophrenia is still prevalent. The effectiveness of augmenting clozapine : one augmenting with haloperidol and the other with electroconvulsive therapy should be determined. This study is a randomized control trial.

Clinical Details

Official title: Treatment of Clozapine-resistant Schizophrenia : Comparison Between Augmentation With Haloperidol and Electroconvulsive Therapy

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: PANSS , HAM-D , CGI , AIMS Scores


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria: 1. schizophrenic patients diagnosed with schedules for clinical assessment in neuropsychiatry ( SCAN )in accordance with DSM-IV-TR or ICD-10 2. Resistant to at least 6 weeks of clozapine treatment in therapeutic dosage 3. Voluntary to participate the research protocol expressed by signing informed consent form Exclusion Criteria: 1. Patient does not volunteer himself or herself 2. Patient is having epilepsy, DM, cardiac disease, autistic disorder and illiterate 3. Patient is deaf, blind , dumb to obstruct good communication

Locations and Contacts

Department of Psychiatry.Faculty of Medicine.KhonKaen University., Muang, KhonKaen 40002, Thailand
Additional Information

Starting date: June 2008
Last updated: May 4, 2012

Page last updated: August 23, 2015

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