Low Molecular Weight Heparin in Recurrent Implantation Failure
Information source: V.K.V. American Hospital, Istanbul
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Infertility; Fertilization in Vitro; Recurrent Implantation Failure
Intervention: low molecular weight heparin (enoxaparine sodium) (Drug); crinone 8% gel (Drug)
Phase: N/A
Status: Completed
Sponsored by: V.K.V. American Hospital, Istanbul Official(s) and/or principal investigator(s): Cumhur B Urman, M.D., Study Director, Affiliation: American Hospital of Istanbul
Summary
Recurrent implantation failure is the failure to achieve a pregnancy after multiple attempts
with in vitro fertilization treatment. The reason is usually obscure. Many empirical
treatments have been offered without substantial evaluation. Heparin is thought to play a
role in the embryo implantation process beyond its anticoagulation effects. The proposed
study aims to assess the effectiveness and safety of empirical administration of low
molecular weight heparin in patients undergoing a new IVF treatment cycle after multiple
failed attempts.
Clinical Details
Official title: Empirical Low Molecular Weight Heparin Administration in the Luteal Phase in Patients With Recurrent Implantation Failures: a Randomized Open Labeled Trial
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Ongoing pregnancy beyond the 20th gestational week rate
Secondary outcome: Clinical pregnancy rateEmbryo implantation rate
Eligibility
Minimum age: 18 Years.
Maximum age: 38 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- History of at least two previously failed fresh embryo transfer cycles
- All previously failed cycles to be performed in the American Hospital of Istanbul
- Female age ≤ 38 years
- Fresh ejaculate sperms to be used for ICSI
- No hormonal, coagulation, or immunological disorders detected
- Normal uterine cavity, as assessed by diagnostic office hysteroscopy or saline
infusion sonography
- Normal female and male peripheral karyotype
Locations and Contacts
Assisted Reproduction Unit of the American Hospital of Istanbul, Istanbul 34365, Turkey
Additional Information
Starting date: January 2006
Last updated: March 19, 2009
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