Pilot Study Evaluating Interruption of Enfuvirtide (Fuzeon, T20) in Patients With Enfuvirtide Resistance

Condition(s) targeted: HIV Infections

Intervention: Interruption of enfuvirtide (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: University of California, San Francisco

Official(s) and/or principal investigator(s):
Steven G Deeks, M.D., Principal Investigator, Affiliation: University of California, San Francisco

The goal of this study is to examine whether enfuvirtide (T20, Fuzeon) has continued anti-HIV activity in patients experiencing an incomplete virologic response to an enfuvirtide-based regimen.

Official title: Partial Treatment Interruptions in HIV-1 Patients With Multi-Drug Resistant Virus

Study design: Diagnostic, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Efficacy Study

Primary outcome:

CD4

viral load

resistance assays at weeks 4, 12, 24, 48 after enfuvirtide interruption

Detailed description: Some patients do not achieve an undetectable HIV viral load with an enfuvirtide (T20, Fuzeon) based antiretroviral regimen. As a consequence, enfuvirtide resistant virus can emerge. It is not yet known if enfuvirtide has continued virologic or immunologic benefit after the drug-resistant variant emerges. Interrupting enfuvirtide may reduce the accumulation of enfuvirtide mutations and may allow for a potent response of enfuvirtide with future regimens.

Subjects must have evidence of viral replication (HIV RNA > 1,000 copies/ml on two consecutive measurements) while on a stable antiretroviral regimen containing enfuvirtide. Patients will then interrupt enfuvirtide while continuing all other antiretroviral agents. Subjects will be seen weekly for four weeks, every two weeks for an additional 8 weeks, and then every four weeks through week 48.

Plasma HIV RNA levels and CD4+/CD8+ T cell counts will be measured in real time at each visit, and provided to the referring primary care physician. Subjects will be allowed to resume enfuvirtide at any time during the course of this study. Subjects will be encouraged to resume enfuvirtide (with or without modifying the background regimen) if plasma HIV RNA levels increase by > 0. 5 log on two consecutive occasions. Subjects are seen every four weeks for 24 weeks after enfuvirtide is resumed.

Plasma will be collected at those visits for HIV RNA and stored for retrospective genotype/phenotype evaluation.

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Currently receiving continuous enfuvirtide-based antiretroviral therapy.

- Documentation of recent plasma HIV RNA level greater than the lower limit of detection

(measured within the preceding 4 weeks)

- Screening plasma HIV-1 RNA level > 1000 copies/mL.

- Negative serum pregnancy test (for women of childbearing potential) documented within

the 14-day period prior to study entry.

- Subjects must be able to give written informed consent and agree to abide by the

requirements of the study.

Exclusion Criteria:

- Unstable HIV disease status such that interrupting any antiretroviral therapy poses

significant short-term risk for disease progression (as determined by study investigators and referring primary care provider).

- Female subjects who are pregnant, breastfeeding, or who plan to become pregnant during

the study.

- Active hepatitis C infection requiring treatment with an interferon-based regimen.

- Evidence of active, untreated opportunistic infections or unexplained temperature

which is > 38. 5°C for seven consecutive days, within 30 days prior to the first screening visit.

San Francisco General Hospital, San Francisco, California 94110, United States

Starting date: May 2000
Last updated: June 16, 2006