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Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3

Information source: University of Chicago
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Opioid-Related Disorders; Substance-Related Disorders

Intervention: 30% N2O (Drug); 0.2% isoflurane (Drug); 0.4% isoflurane (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: University of Chicago

Official(s) and/or principal investigator(s):
James Zacny, Ph.D., Principal Investigator, Affiliation: University of Chicago

Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.

Clinical Details

Official title: Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome:

Logical reasoning test

Free recall memory test

Auditory reaction time

Digit symbol substitution test

Eligibility

Minimum age: 21 Years. Maximum age: 32 Years. Gender(s): Both.

Criteria:

Please contact site for information.

Locations and Contacts

University of Chicago, Anesthesia & Critical Care, Chicago, Illinois 60637, United States
Additional Information

Related publications:

Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL. The acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and psychomotor performance in healthy volunteers. Anesth Analg. 1996 Jan;82(1):153-7.

Starting date: April 1994
Last updated: May 26, 2015

Page last updated: August 23, 2015

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