Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3
Information source: University of Chicago
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Opioid-Related Disorders; Substance-Related Disorders
Intervention: 30% N2O (Drug); 0.2% isoflurane (Drug); 0.4% isoflurane (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: University of Chicago Official(s) and/or principal investigator(s): James Zacny, Ph.D., Principal Investigator, Affiliation: University of Chicago
Summary
The purpose of this study is to conduct experiments to examine subjective and reinforcing
effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug
abusers and preference procedures will be used to assess reinforcing effects. To evaluate
the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide
combinations in healthy volunteers.
Clinical Details
Official title: Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Primary outcome: Logical reasoning testFree recall memory test Auditory reaction time Digit symbol substitution test
Eligibility
Minimum age: 21 Years.
Maximum age: 32 Years.
Gender(s): Both.
Criteria:
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Locations and Contacts
University of Chicago, Anesthesia & Critical Care, Chicago, Illinois 60637, United States
Additional Information
Related publications: Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL. The acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and psychomotor performance in healthy volunteers. Anesth Analg. 1996 Jan;82(1):153-7.
Starting date: April 1994
Last updated: May 26, 2015
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