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Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers

Information source: Jagiellonian University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Denture Stomatitis

Intervention: Nystatin (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Jagiellonian University

Official(s) and/or principal investigator(s):
Tomasz Guzik, MD, PhD, Principal Investigator, Affiliation: Jagiellonian University
Marta Cześnikiewicz-Guzik, PhD, Principal Investigator, Affiliation: Jagiellonian University

Overall contact:
Marta Cześnikiewicz-Guzik, PhD, Phone: +48126330003, Email: marta.czesnikiewicz-guzik@glasgow.ac.uk

Summary

The aim of this study is to evaluate the influence of presence of oral fungal infection, which leads to denture-related stomatitis, on blood pressure, endothelial function and immune cell phenotype in patients wearing dentures.

Clinical Details

Official title: Effects of Denture-Related Stomatitis on Blood Pressure, Endothelial Function and Systemic Immune Response in Patients With Dentures

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: Change from baseline in blood pressure

Secondary outcome:

Change from baseline in endothelial function

Changes in immune cell subset populations from baseline

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with dental prostheses used for at least 6 months,

- Substantial portion of the oral mucosa covered by dental prosthesis.

Exclusion Criteria:

- acute inflammatory disorders other than denture-related stomatitis, neoplastic

disease relapses or chemotherapy courses less than 5 years before the enrolment,

- antibiotics in less than 4 weeks before the enrolment,

- anti-inflammatory drugs (steroids and non-steroidal, excluding aspirin in doses less

than 80 mg) in less than 2 months before the enrolment,

- history of myocardial infarction, acute coronary incident or vascular inflammation in

5 weeks or less before the enrolment,

- chronic haematological disorders and immunodeficiencies less than 5 weeks before the

enrolment,

- major medication changes less than 5 weeks before the enrolment or during study.

Locations and Contacts

Marta Cześnikiewicz-Guzik, PhD, Phone: +48126330003, Email: marta.czesnikiewicz-guzik@glasgow.ac.uk

Jagiellonian University Dental Clinic, Krakow 31-155, Poland; Recruiting

Zbigniew Żak Voivodeship Dental Clinic, Krakow 31-135, Poland; Recruiting

Additional Information

Starting date: October 2011
Last updated: June 18, 2014

Page last updated: August 23, 2015

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