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International Ataxia Rating Scale in Younger Patients

Information source: Erydel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Ataxia Telangiectasia

Phase: N/A

Status: Completed

Sponsored by: Erydel

Official(s) and/or principal investigator(s):
Luca Benatti, MD, Study Director, Affiliation: Erydel

Summary

The project will collect information on the mapping of clinical ratings on a number of scales that are used in the assessment of patients with ataxias.

Clinical Details

Official title: APPLICABILITY OF THE INTERNATIONAL ATAXIA RATING SCALE (ICARS) IN YOUNGER PATIENTS AND DEVELOPMENT OF GLOBAL RATING INSTRUMENTS FOR PATIENTS WITH ATAXIA TELANGIECTASIA (AT)

Study design: Time Perspective: Prospective

Primary outcome: Correlation Analysis

Eligibility

Minimum age: 6 Years. Maximum age: 18 Years. Gender(s): Both.

Criteria:

Inclusion criteria 1. Patients aged 6-18 years with diagnosed with ataxia, preferably AT will be included. The diagnosis of AT will be made based on the criteria: typical clinical picture plus one of the following: 1. a proven mutation in the ATM gene 2. Deficient ATM protein proven by Western blotting 3. Elevated ╬▒-fetoprotein, cerebellar atrophy on MRI and immune deficiency/ chromosomal breakage/ T- cell lymphoreticular malignancy. 2. Children aged 6-18 years with suspected AT (fulfilling partially the above criteria will be included) 3. Children aged 6-18 years with AT like disease, with or without proven mutation in the MRE11 gene will be included 4. Children aged 6-18 years of age with ataxia of other known or unknown etiologies might be included, but their total number should not exceed 20% of the cohort in each site

Locations and Contacts

Jaslok Hospital, Mumbai, India

Edmond and Lilly Safra Childrens Hospital Pediatric Unit, Tel Hashomer, Israel

A.O Spedalli Civilli Brescia, Brescia, Italy

Università La Sapienza, Roma 00100, Italy

Carol Morsani USF Health Center, Tampa, Florida, United States

Additional Information

Starting date: August 2013
Last updated: December 30, 2014

Page last updated: August 23, 2015

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