International Ataxia Rating Scale in Younger Patients
Information source: Erydel
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Ataxia Telangiectasia
Phase: N/A
Status: Completed
Sponsored by: Erydel Official(s) and/or principal investigator(s):
Luca Benatti, MD, Study Director, Affiliation: Erydel
Summary
The project will collect information on the mapping of clinical ratings on a number of
scales that are used in the assessment of patients with ataxias.
Clinical Details
Official title: APPLICABILITY OF THE INTERNATIONAL ATAXIA RATING SCALE (ICARS) IN YOUNGER PATIENTS AND DEVELOPMENT OF GLOBAL RATING INSTRUMENTS FOR PATIENTS WITH ATAXIA TELANGIECTASIA (AT)
Study design: Time Perspective: Prospective
Primary outcome: Correlation Analysis
Eligibility
Minimum age: 6 Years.
Maximum age: 18 Years.
Gender(s): Both.
Criteria:
Inclusion criteria
1. Patients aged 6-18 years with diagnosed with ataxia, preferably AT will be included.
The diagnosis of AT will be made based on the criteria: typical clinical picture plus
one of the following: 1. a proven mutation in the ATM gene 2. Deficient ATM protein
proven by Western blotting 3. Elevated α-fetoprotein, cerebellar atrophy on MRI and
immune deficiency/ chromosomal breakage/ T- cell lymphoreticular malignancy.
2. Children aged 6-18 years with suspected AT (fulfilling partially the above criteria
will be included)
3. Children aged 6-18 years with AT like disease, with or without proven mutation in the
MRE11 gene will be included
4. Children aged 6-18 years of age with ataxia of other known or unknown etiologies
might be included, but their total number should not exceed 20% of the cohort in each
site
Locations and Contacts
Jaslok Hospital, Mumbai, India
Edmond and Lilly Safra Childrens Hospital Pediatric Unit, Tel Hashomer, Israel
A.O Spedalli Civilli Brescia, Brescia, Italy
Università La Sapienza, Roma 00100, Italy
Carol Morsani USF Health Center, Tampa, Florida, United States
Additional Information
Starting date: August 2013
Last updated: December 30, 2014
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