Effects of Berries on Post-meal Blood Sugar
Information source: University of Eastern Finland
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Blood Glucose, Postprandial; Blood Insulin, Postprandial; Hyperglycemia
Intervention: Berries (Other); No berries (Other)
Phase: N/A
Status: Completed
Sponsored by: Marjukka Kolehmainen Official(s) and/or principal investigator(s): Riitta Törrönen, Dr, Principal Investigator, Affiliation: Senior Scientist
Summary
The purpose of this study is to investigate whether berries are effective in lowering blood
glucose and insulin responses to meals containing starch or sucrose.
Clinical Details
Official title: Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch
Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: Plasma glucosePlasma insulin
Secondary outcome: Plasma free fatty acids
Detailed description:
Berries are rich sources of various polyphenols which may be beneficial in the regulation of
blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich
extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates
and thereby suppress postprandial glycemia. However, current evidence on the effects of
berries on postprandial glycemic responses in humans is limited.
The purpose of this study is to investigate the effects of berries on postprandial glycemic
responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists
of five substudies each of which includes 2-4 meals with different berry species typically
consumed in Finland and a reference meal without berries. The following combinations of
carbohydrates and berries are studied:
- Studies 1-2: white wheat bread (starch) is consumed with several berry species
- Study 3: white wheat bread or rye bread is consumed with a mixture of berries
- Study 4: sugar (sucrose) is consumed with berries and berry nectars
- Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries
and berry nectar.
Eligibility
Minimum age: 25 Years.
Maximum age: 69 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- BMI 20-28 kg/m2
- normal fasting plasma glucose
Exclusion Criteria:
- Smoking
- Diabetes or other chronic disease
- Antibiotic medication within the past 3 months
- Blood donation within the past month
Locations and Contacts
University of Eastern Finland, Kuopio FI-70211, Finland
Additional Information
Starting date: November 2009
Last updated: April 16, 2012
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