This randomized, open-label, multi-center study will evaluate the sustained virological
response, pharmacokinetics and safety of various combinations of danoprevir/ritonavir with
Copegus plus RO5024048 and/or Pegasys in patients with chronic hepatitis C infection.
Patients will be divided into 2 separate cohorts. Cohort A, previous partial responders,
will be randomized to Groups 1-3 and cohort B, previous null responders, will be randomized
to Groups 4-6. Patients in all groups will receive danoprevir 100 mg twice a day and
ritonavir 100 mg twice a day for 24 weeks. In addition, Groups 1 and 4 will receive
RO5024048 1000 mg twice a day and Copegus 1000 mg or 1200 mg twice a day for 24 weeks; Group
2 will receive Pegasys 180 microgram subcutaneously once weekly and Copegus 1000 mg or 1200
mg twice a day for 24 weeks; Groups 3, 5 and 6 will receive RO5024048 1000 mg twice a day,
Pegasys 180 microgram subcutaneously once weekly and Copegus 1000 mg or 1200 mg twice a day
for 24 weeks. In addition, patients in Group 6 will receive another 24 weeks of Pegasys plus
Copegus treatment.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Wien 1090, Austria
La Tronche 38700, France
Paris 75651, France
Paris 75679, France
Pessac 33604, France
Vandoeuvre-les-nancy 54511, France
Berlin 13353, Germany
Essen 45122, Germany
Kiel 24105, Germany
Tübingen 72076, Germany
Guadalajara 44650, Mexico
Guadalajara 44280, Mexico
Bydgoszcz 85-030, Poland
Czeladz 41-250, Poland
Kielce 25-317, Poland
Warszawa 01-201, Poland
Łodz 91-347, Poland
San Juan 00927, Puerto Rico
Barcelona 08003, Spain
Madrid 28034, Spain
Madrid 28222, Spain
Sevilla 41014, Spain
Birmingham B15 2TH, United Kingdom
Dundee DD1 9SY, United Kingdom
London E1 1BB, United Kingdom
London W2 1PG, United Kingdom
Manchester M8 5RB, United Kingdom
Calgary, Alberta T2N 4Z6, Canada
Edmonton, Alberta T6G 2B7, Canada
Badalona, Barcelona 08915, Spain
Vancouver, British Columbia V5Z 1H2, Canada
Vancouver, British Columbia V5Z 1M9, Canada
Vancouver, British Columbia V6Z 2K5, Canada
La Jolla, California 92037-1030, United States
Long Beach, California 90822, United States
Sacramento, California 95817, United States
San Diego, California 92103, United States
Napoli, Campania 80135, Italy
Aurora, Colorado 80045, United States
Orlando, Florida 32804, United States
Decatur, Georgia 30033, United States
Chicago, Illinois 60637, United States
Milano, Lombardia 20162, Italy
Pavia, Lombardia 27100, Italy
New Orleans, Louisiana 70112, United States
Detroit, Michigan 48202-2689, United States
Darlinghurst, New South Wales 2010, Australia
Kingswood, New South Wales 2747, Australia
Westmead, New South Wales 2145, Australia
Manhasset, New York 11030, United States
New York, New York 10021, United States
Chapel Hill, North Carolina 27599-7584, United States
London, Ontario N6A 5A5, Canada
Ottawa, Ontario K1H 8L6, Canada
Toronto, Ontario M5G 1L7, Canada
Medford, Oregon 97504, United States
Porto Alegre, RS 90035-003, Brazil
Providence, Rhode Island 02905, United States
Ribeirao Preto, SP 14049-900, Brazil
Adelaide, South Australia 5000, Australia
Nashville, Tennessee 37211, United States
Houston, Texas 77030, United States
San Antonio, Texas 78215, United States
San Antonio, Texas 78234, United States
Pisa, Toscana 56124, Italy
Melbourne, Victoria 3004, Australia
Melbourne, Victoria 3186, Australia