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Physostigmine After General Anesthesia

Information source: Bispebjerg Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Nausea and Vomiting; Anesthesia Recovery Period

Intervention: physostigmine (Drug); Isotonic sodium chloride solution (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Bispebjerg Hospital

Official(s) and/or principal investigator(s):
Frank Pott, MD, Study Director, Affiliation: Bispebjerg Hospital

Overall contact:
Frank Pott, MD, Phone: +4535313531, Ext: 4358, Email: frank.pott@gmail.com


Recovery after general anaesthesia is often prolonged in the elderly. This group is particularly exposed to post-operative confusion. This has negative personal consequences as well as consequences for the postoperative care for these patients. The hypothesis is that physostigmine will decrease the amount of time in the post-anaesthesia care unit (PACU ), the postoperative amount of pain and shivering and finally post-operative confusion.

Clinical Details

Official title: The Use of Physostigmine in Elderly Patients in the Postoperative Recovery-phase After General Anesthesia

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: The readiness to be released from the PACU (assessed by the normal guidelines) It should be noted that for safety reasons the patients remained in the PACU for at least 60 minutes

Secondary outcome: Pain, shivering and nausea will also be registered on the standardized form as well as a multiple of physiological measurements. A follow-up will be performed after 12 hours from release from the PACU

Detailed description: The researchers wish to investigate the use of physostigmine in the elderly patients (age > 60 yrs, ASA I-III) in the postoperative recovery-phase after general anesthesia. Apart from the beneficial effects for the patient, the lessened amount of time in the PACU will release caregiving resources and thereby increase the efficacy of the PACU.


Minimum age: 60 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Scheduled for surgical acute or elective operation

- General anesthesia.

- ASA physical status I-III

- Age > 60 years

Exclusion Criteria:

- Asthma and chronic pulmonary diseases

- Glaucoma

- Diabetics

- Any history of neurological and psychiatric disorder

- Parkinson's disease

- Disorders of the gastrointestinal and urogenital tracts

Locations and Contacts

Frank Pott, MD, Phone: +4535313531, Ext: 4358, Email: frank.pott@gmail.com

Bispebjerg Hospital, Copenhagen, Copenhagen NV 2400, Denmark; Recruiting
Carsten M Pedersen, cand.cur., Phone: +4535313983, Email: cped0070@bbh.regionh.dk
Additional Information

Starting date: December 2009
Last updated: May 26, 2010

Page last updated: August 23, 2015

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