Effects of H1-Antagonist on Cognition
Information source: Maastricht University Medical Center
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cognition
Intervention: dexchlorpheniramine, lorazepam (Drug)
Phase: N/A
Status: Completed
Sponsored by: Maastricht University Medical Center Official(s) and/or principal investigator(s): Annemiek Vermeeren, Ph.D., Principal Investigator, Affiliation: Maastricht University hospital
Summary
The purpose of this study is to determine whether histamine is involved in memory and
specific processes in human cognition.
Clinical Details
Official title: Effects of H1-Antagonist on Stages of Human Information Processing
Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
Primary outcome: P300 latency and LRP onset latency
Secondary outcome: Words recalled
Detailed description:
The neurotransmitter histamine appears to be involved in human cognitive performance.
However, the exact role is very unclear. The role it plays in memory performance is highly
disputed, as animal studies show decreased performance when the H1-receptor is blocked in
the central nervous system while such findings in humans is scarce. To clarify the role of
histamine in human memory and different processes in cognition, the effects of an
H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are
measured. The study will be conducted according to a within subject cross-over design using
healthy volunteers.
Eligibility
Minimum age: 18 Years.
Maximum age: 45 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Healthy as determined by a physician
Exclusion Criteria:
- present or history of any neurological of psychiatric disease
- present or history of any substance abuse
Locations and Contacts
Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Limburg 6229 ER, Netherlands
Additional Information
webpage of the experimental psychopharmacology unit of the Maastricht University
Starting date: December 2006
Last updated: February 18, 2009
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