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Effects of H1-Antagonist on Cognition

Information source: Maastricht University Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cognition

Intervention: dexchlorpheniramine, lorazepam (Drug)

Phase: N/A

Status: Completed

Sponsored by: Maastricht University Medical Center

Official(s) and/or principal investigator(s):
Annemiek Vermeeren, Ph.D., Principal Investigator, Affiliation: Maastricht University hospital


The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.

Clinical Details

Official title: Effects of H1-Antagonist on Stages of Human Information Processing

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: P300 latency and LRP onset latency

Secondary outcome: Words recalled

Detailed description: The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.


Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Both.


Inclusion Criteria:

- Healthy as determined by a physician

Exclusion Criteria:

- present or history of any neurological of psychiatric disease

- present or history of any substance abuse

Locations and Contacts

Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Limburg 6229 ER, Netherlands
Additional Information

webpage of the experimental psychopharmacology unit of the Maastricht University

Starting date: December 2006
Last updated: February 18, 2009

Page last updated: August 23, 2015

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