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Bacillus Calmette-Guerin Followed by Sunitinib for the Treatment of High Risk Non-muscle Invasive Lower Urinary Tract Urothelial Carcinoma

Information source: University of Michigan
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Urinary Tract Urothelial Carcinoma

Intervention: Sunitinib (Drug)

Phase: Phase 2

Status: Active, not recruiting

Sponsored by: University of Michigan

Official(s) and/or principal investigator(s):
Alon Weizer, MD, Principal Investigator, Affiliation: University of Michigan

Summary

A majority of patients with bladder cancer have disease confined to the inner lining of the bladder. Patients with high risk features (high grade tumors, tumors invading into a deeper superficial layer) are routinely treated with Bacillus Calmette Guerin (BCG) instilled in their bladder after the tumor has been removed. While up to 55% of patients respond to BCG, failure to respond may suggest a more aggressive tumor that requires more definitive therapy with complete bladder removal. BCG is believed to work by stimulating the body's own immune system to attack tumor cells. It may also work by blocking the machinery that tumors use to grow blood vessels which fuel tumor growth. A newer oral drug, sunitinib has shown to help patients with metastatic bladder cancer by blocking new blood vessel growth (VEGF inhibition). The investigators are studying the use of BCG followed by sunitinib in patients with high risk non-muscle invasive bladder cancer to evaluate the complete response (no visible evidence of tumor in the bladder) at 3 months and 6 months. The investigators will also evaluate whether there is recurrent tumor at three years.

Clinical Details

Official title: A Phase II Study of Intravesical Bacillus Calmette-Guerin Followed by Sunitinib for the Treatment of High Risk Non-muscle Invasive Lower Urinary Tract Urothelial Carcinoma

Study design: Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Determine complete response rate at 3 months in patient with high risk non-invasive urothelial carcinoma of the lower urinary tract treated with a intravesical BCG followed by sunitinib

Secondary outcome:

Determine complete response percentage of study regimen at 6 months.

Assess recurrence-free survival at 2 years in patients with intact bladder.

Determine toxicity related to treatment with BCG followed by Sunitinib.

Detailed description: Despite a complete response of 45-55% in patients with non-muscle invasive urothelial carcinoma involving the lower urinary tract at 3 months, many patients suffer from multiple recurrences and progression in up to 1/3 of patients. While radical cystectomy is an effective local therapy for patients with high risk non-invasive disease, roughly 15% of patients will still develop progression. More importantly, the morbidity of radical cystectomy as described above represents a barrier to treatment in some individuals. Thus, there is a real need to identify newer therapies that reduce morbidity and improve outcomes in patients with non-invasive urothelial cancer. While multiple drug regimens have been the standard for many forms of cancer including invasive bladder cancer, few reports exist on multidrug regimens for non-invasive bladder cancer. The fundamentally agreed upon mechanism of action of BCG intravesical therapy for superficial bladder cancer is the generation of a non-specific immune response with the expression of cytokines by inflammatory cells resulting in tumor death. Cytokines produced by BCG therapy such as IFN╬▒ may block vascular endothelial growth factor (VEGF) which is expressed in superficial and invasive bladder cancer and may provide a mechanism for disease progression. Sunitinib is an oral tyrosine kinase inhibitor that blocks VEGF. Recent reports demonstrate clinical response in patients with metastatic bladder cancer treated with sunitinib after recurrence following standard chemotherapeutic regimens. The addition of sunitinib following BCG in order to consolidate VEGF inhibition may result in superior 3 month complete response rates. We know that patients who have a complete response to BCG at 3 months have improved disease.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients must have histologically confirmed urothelial carcinoma confined to the

urinary bladder and/or prostatic urethra by bladder biopsy within 6 weeks of study enrollment.

- Patients are eligible if the biopsy was done within 3 months of enrollment and a

cystoscopy demonstrates no gross disease within 6 weeks of enrollment.

- Tumor histology with >50% transitional cell carcinoma histology

- Tumor stage less than or equal to T1 confirmed by pathology report

- Patients with a T1 tumor will require a restaging TURBT confirming no higher stage

tumor prior to study enrollment

- High grade tumor as defined by the WHO/ISUP 1998 classification system. (Presence of

carcinoma in situ constitutes a high grade tumor)

- No BCG within 12 months of enrollment

- Patients are allowed to have received a single dose of intravesical chemotherapy

(excluding BCG) in the operating room following transurethral resection documenting non-muscle invasive urothelial carcinoma of the lower urinary tract.

- Patients are allowed to have received a previous 6 week cycle of any standard

intravesical chemotherapy if > 3 months prior to enrollment.

- Age >18 years.

- ECOG performance status 0 or 1

- Patients must have adequate organ and marrow function as defined below:

- absolute neutrophil count > 1,500/mcL

- platelets > 100,000/mcL

- total bilirubin less than or equal to 1. 5 upper limit of normal

- AST(SGOT)/ALT(SGPT) less than or equal to 2. 5 X institutional upper

- limit of normal

- Serum creatinine < 2. 0 mg/dl

- MUGA scan within institutional normal limits

- Timing guideline for pre-study labs and measurements:

- All pre-study labs required for determination of eligibility are to be completed

within 6 weeks prior to registration.

- X-rays and/or scans to determine disease status are to be completed within 6 months

prior to registration (or the next business day if falls on a weekend or holiday). Exclusion Criteria:

- Patients with a prior history of radiation for bladder cancer

- Patients with a prior history of radiation for prostate cancer are eligible for the

study

- Greater than or equal to T2N0M0 transitional cell carcinoma of the bladder on current

pathology or in the past

- Patients with a prior history of upper tract urothelial carcinoma are eligible for

participation in the study as long as there is no evidence of disease for 6 months prior to study enrollment

- Patients with other malignancies are eligible for enrollment in the study but should

not be on active treatment for this malignancy within 12 months of study enrollment. Patients with prior history of local treatment for prostate cancer are eligible for participation in the study

- Patients cannot have received Sunitinib or other anti-angiogenic therapy for at least

12 months prior to enrollment in the study

- History of allergic reactions attributed to compounds of similar chemical or biologic

composition to BCG and Sunitinib

- Patients with prior systemic infection with BCG are not eligible for the study

- Patients with prior intolerance to BCG may be considered

- Major incisional surgery within 4 weeks of study enrollment

- Bleeding diathesis or unresolved gross hematuria after bladder biopsy

- Known HIV - positive patients may not participate. This is to avoid additional

complications that immune suppression and HIV infection may cause due to treatment with BCG, which is a live attenuated bacteria that is known to cause systemic infection in patients who are immunocompromised.

- Patients taking agents that result in immunosuppression are not eligible for the

study due to the potential for the increased risk of systemic infection in those patients receiving BCG

- Any of the following within the 6 months prior to study drug administration:

myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure (CHF), cerebrovascular accident or transient ischemic attack, or pulmonary embolism.

- Ongoing cardiac dysrhythmias of NCI CTCAE grade 2.

- Patients with history of or who are suspected to have CHF can be included as long as

they are asymptomatic and have an ejection fraction that is equal to or above the institutional lower limit of normal by baseline MUGA (obtained within 28 days of registration or the next business day if falls on a weekend or holiday).

- QTc interval > 500 msec on baseline EKG (to be done within 6 weeks prior to

registration or the next business day if falls on a weekend or holiday).

- Hypertension that cannot be controlled by medications (>150/100 mm Hg despite optimal

medical therapy).

- Patient may not have unresolved bacterial infection.

- Patients with hypothyroidism that can not be adequately controlled with medication

will be excluded. All patients will be monitored at trial initiation with a TSH.

- Concurrent treatment on another clinical trial. Supportive care trials or

non-treatment trials, e. g. QOL, are allowed.

- Pregnancy or breastfeeding. Female subjects must be surgically sterile or be

postmenopausal, or must agree to use effective contraception during the period of therapy.

- All female subjects with reproductive potential must have a negative pregnancy test

(serum or urine) prior to enrollment.

- Male subjects must be surgically sterile or must agree to use effective contraception

during the period of therapy.

- The definition of effective contraception will be based on the judgment of the

principal investigator or a designated associate.

- Other severe acute or chronic medical or psychiatric condition or laboratory

abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into this study.

Locations and Contacts

Mark P. Schoenberg, MD, Baltimore, Maryland 21287-2101, United States

Alon Weizer, MD, Ann Arbor, Michigan 48109, United States

Additional Information

Starting date: January 2009
Last updated: August 11, 2015

Page last updated: August 23, 2015

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