Cortisol in the Treatment of Phobias
Information source: University of Zurich
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Phobia
Intervention: Cortisol (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: University of Zurich Official(s) and/or principal investigator(s):
Dominique JF de Quervain, MD, Prof., Principal Investigator, Affiliation: University of Zürich
Frank Wilhelm, Prof., Principal Investigator, Affiliation: University Hospital, Basel, Switzerland
Overall contact:
Frank Wilhelm, Professor, Phone: +41 61 267 0593, Email: frank.wilhelm@unibas.ch
Summary
The aim of this prospective, double-blind, placebo-controlled, randomized study is to
investigate if glucocorticoid treatment, in combination with exposure therapy, helps to
reduce phobic fear in patients with phobia.
Clinical Details
Official title: The Efficacy of Cortisol in Combination With Behavioral Therapy in the Treatment of Phobias
Study design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: visual analog scales for fear and acrophobia questionnaires
Eligibility
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Female and male patients with a specific phobia (fear of heights) according to DSM-IV
criteria.
Exclusion Criteria:
- Severe acute or chronic somatic diseases
- Psychiatric disorder other than specific phobia
- Topic glucocorticoid therapy (for large skin parts)
- Inhaled glucocorticoids
- Psychotropic medication
- Pregnancy
Locations and Contacts
Frank Wilhelm, Professor, Phone: +41 61 267 0593, Email: frank.wilhelm@unibas.ch
University of Basel, Basel 4055, Switzerland; Recruiting
Frank Wilhelm, Professor, Phone: +41 61 267 0593, Email: frank.wilhelm@unibas.ch
Additional Information
Related publications: Soravia LM, Heinrichs M, Aerni A, Maroni C, Schelling G, Ehlert U, Roozendaal B, de Quervain DJ. Glucocorticoids reduce phobic fear in humans. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5585-90. Epub 2006 Mar 27.
Starting date: May 2007
Last updated: June 2, 2009
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