Additional Glucose Lowering and Anti-Inflammatory Effects by Acarbose and Alcohol in Subjects With Impaired Glucose Tolerance or Mild Type 2 Diabetes

Condition(s) targeted: Diabetes Mellitus; Impaired Glucose Tolerance

Intervention: Acarbose (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Taichung Veterans General Hospital

Official(s) and/or principal investigator(s):
Wayne H Sheu, MD, PhD, Principal Investigator, Affiliation: Taichung Veterans General Hospital

Overall contact:
I Te Lee, MD, MS, Phone: 886-4-23592525, Ext: 3065, Email: itlee@vghtc.gov.tw

To understand if acarbose, an alpha-glucosidase inhibitor usually for treating diabetes, will further lower post meal glucose and inflammatory state when taking together with moderate amount of alcohol during meal tolerance test in subjects with impaired glucose tolerance or mild diabetes.

Study design: Treatment, Randomized, Open Label, Placebo Control, Single Group Assignment, Efficacy Study

Primary outcome: Postprandial hyperglycemia

Secondary outcome:

Postprandial inflammatory responses

Postprandial oxidative stress

Minimum age: 25 Years. Maximum age: 75 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Subjects with mild diabetes without prior medications or impaired glucose tolerance

Exclusion Criteria:

- Pregnancy

- Recent major cardiac, renal and hepatic disease

- Intolerance to alcohol

- Allergy to acarbose treatment

I Te Lee, MD, MS, Phone: 886-4-23592525, Ext: 3065, Email: itlee@vghtc.gov.tw

Taichung Veterans General Hospital, Taichung, Taiwan; Recruiting
Wayne H Sheu, MD, PhD, Phone: 886-4-23592525, Ext: 3068, Email: whhsheu@vghtc.gov.tw
Wayne H Sheu, MD, PhD, Principal Investigator
I Te Lee, MD, MS, Sub-Investigator

Starting date: January 2007
Last updated: January 3, 2007