Antidepressant Treatment in Older Adults With Schizophrenia
Information source: National Institute of Mental Health (NIMH)
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Schizophrenia
Intervention: Citalopram (Celexa) (Drug); Placebo (Drug)
Phase: N/A
Status: Completed
Sponsored by: National Institute of Mental Health (NIMH) Official(s) and/or principal investigator(s):
Sidney Zisook, MD, Principal Investigator, Affiliation: University of California, San Diego
Summary
The purpose of this study is to evaluate the safety and effectiveness of citalopram (Celexa)
for the treatment of depressive symptoms in middle-aged and elderly patients with
schizophrenia.
Clinical Details
Official title: Citalopram Augmentation in Older Patients With Schizophrenia
Study design: Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Parallel Assignment, Safety/Efficacy Study
Detailed description:
Older people with schizophrenia suffer from greater physical comorbidity, cognitive
impairment, and medication side effects compared to their younger counterparts.
Unfortunately, little research is available to guide the treatment of subsyndromal depressive
symptoms in older adults. This study will compare the antidepressant citalopram to placebo to
determine the most effective treatment for reducing depressive symptoms in older patients
with schizophrenia
After patients have been on stable treatment with antipsychotic medication for at least 4
weeks, they are randomly assigned to receive antipsychotic medication plus either citalopram
or placebo for 3 months. Depressive symptoms and side effects are assessed weekly for the
first month, biweekly for the second month, and again at the end of the third month.
Cognition, motor and daily functioning, quality of life, and medication adherence are
assessed throughout the study.
Eligibility
Minimum age: 40 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Schizophrenia or schizoaffective disorder
- HAM-D score of 8 or above
- Antipsychotic medication treatment
Locations and Contacts
San Diego VA Medical Center, San Diego, California 92161, United States
Veterans Administration Hospital of Cincinnati, Cincinnati, Ohio 45220, United States
Additional Information
UCSD Geropsychiatry Advanced Clinical Intervention And Services Research Center
Starting date: September 2001
Ending date: September 2007
Last updated: March 4, 2008
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