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Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy

Information source: Mansoura University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Hypertensive Anal Canal

Intervention: lateral internal sphincterotomy (LIS) (Procedure); Glycerin trinitrate (GTN) (Drug); botulinum toxin injection (BTX A) (Drug)

Phase: N/A

Status: Completed

Sponsored by: Mansoura University

Official(s) and/or principal investigator(s):
ayman elnakeeb, MD, Principal Investigator, Affiliation: mansoura university hospital

Summary

Idiopathic hypertensive anal canal is a fact and already exists presented by anal pain aggravated by defecation. It can be managed safely by closed lateral sphincterotomy but chemical sphincterotomy had a minor role in its management.

Clinical Details

Official title: Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome:

Effect of Closed Lateral Sphincterotomy and Chemical Sphincterotomy on Hypertensive Anal Canal

Relieve of Anal Pain

Detailed description: Patient and methods: Sixty three patients complaining of anal pain without any anal pathology and 10 healthy volunteers were examined. All patients underwent clinical evaluation, neurological examination, anorectal manometry, and measurement of pudendal nerve terminal motor latency (PNTML). All patients with hypertensive anal canal were randomized into three groups. Group I (surgical group) underwent closed lateral sphincterotomy LS, group II using nitroglycerine ointment (GTN) and group III received injection of botulinum toxin in internal sphincter. Post procedures data were recorded at follow up period.

Eligibility

Minimum age: 18 Years. Maximum age: 61 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- all patients with hypertensive anal canal

Exclusion Criteria:

- patients who had any pathological anorectal lesions such as anal fissure, piles,

rectal prolapse, intussusception, anismus, cancer, patients with normal anal pressure

- patients who previously had anorectal surgery, chemical or surgical sphincterotomy,

anal dilatation, IBD, venereal disease, neurological disorder or systemic gastrointestinal disease

Locations and Contacts

Ayman Elnakeeb, Mansoura 335111, Egypt
Additional Information

Starting date: September 2002
Last updated: May 7, 2009

Page last updated: August 23, 2015

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