Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers
Information source: Medical University of Vienna
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Sepsis
Intervention: oxytocin (Drug)
Phase: N/A
Status: Completed
Sponsored by: Medical University of Vienna Official(s) and/or principal investigator(s):
Martin Clodi, MD, Associate Professor, Principal Investigator, Affiliation: Medical University of Vienna
Summary
The aim of this study is to determine if oxytocin administration is able to blunt LPS induced
increase of cytokines (TNF-α) and if there is a change in the endocrine response after
lipopolysaccharide administration in humans.
Clinical Details
Official title: Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers
Study design: Prospective
Primary outcome: TNF-alpha
Secondary outcome: ACTH, cortisol, procalcitonin, IL-1ra, IL-4, IL-6,
MIP-1alpha, MIP-1 beta, MCP-1, IP-10, VEGF, body temperature, BNP, Ghrelin,
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Men aged 18 years or older with no disease history
- Written informed consent
Exclusion Criteria:
- Receiving any medication
- Probands who suffer from infectious disease
Locations and Contacts
Medical University of Vienna, Vienna 1090, Austria
Additional Information
Starting date: August 2006
Last updated: December 10, 2007
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