Effect of Yohimbine on Colon Transit
Information source: Mayo Clinic
Information obtained from ClinicalTrials.gov on December 31, 2007
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy Volunteers
Intervention: Yohimbine, oral (Drug)
Phase: Phase 1/Phase 2
Status: Recruiting
Sponsored by: Mayo Clinic Official(s) and/or principal investigator(s):
Adil E Bharucha, MBBS, M.D., Principal Investigator, Affiliation: Mayo Clinic
Summary
This study is being done to learn if yohimbine, a naturally occurring drug, affects the speed
at which food travels through the stomach, intestines and colon, and if yohimbine affects the
amount of liquid you can drink in a short period of time. Understanding how yohimbine works
on the gut may help develop new treatments for patients with constipation. Yohimbine has been
approved by the Food and Drug Administration (FDA) for routine clinical use, however, its use
as proposed in this study is considered investigational.
Clinical Details
Official title: Effect of Oral Yohimbine on Colonic Transit: Randomized, Placebo-Controlled Trial
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: Colonic transit
Secondary outcome: Small bowel transit timeGastric emptying time Maximum tolerated volume ingested during satiation testing Average stools per day Stool consistency
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Healthy male or non-pregnant, non-breastfeeding female volunteers, - 18-65 years old;
Able to provide written informed consent before participating in the study;
Able to communicate adequately with the investigator and to comply with the requirements
for the entire study.
Locations and Contacts
Mayo Clinic, Rochester, Minnesota 55905, United States; Recruiting
Barb Seide, Phone: 507-255-6802
Adil E Bharucha, MBBS, MD, Principal Investigator
Additional Information
Starting date: June 2005
Ending date: October 2005
Last updated: September 16, 2005
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