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Antagonist Protocol in Poor Responders

Information source: Cairo University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Female Infertility Due to Diminished Ovarian Reserve

Intervention: Growth Hormone (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Cairo University

Official(s) and/or principal investigator(s):
Yomna A Bayoumi, MD, Principal Investigator, Affiliation: Cairo University


The effect of use of the growth hormone with antagonist protocol on the outcome of the IVF/ICSI cycles in poor responders.

Clinical Details

Official title: Does the Addition of Growth Hormone to the Invitro Fertilization/ Intracytoplasmic Sperm Injection Antagonist Protocol Improve Outcome in Poor Responders? A Randomized Controlled Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Live birth rate

Secondary outcome: Clinical pregnancy rate

Detailed description: Two groups of poor responder female patients planned to receive the antagonist IVF/ICSI protocol are randomized to whether or not to add growth hormone to their protocol.


Minimum age: 20 Years. Maximum age: 45 Years. Gender(s): Female.


Inclusion Criteria:

- females fulfilling the criteria of the ESHRE consensus 2011:

- at least two of the following three features must be present:

- dvanced maternal age (≥40 years) or any other risk factor for POR

- previous POR (≤3 oocytes with a conventional stimulation protocol)

- an abnormal ovarian reserve test (i. e. AFC ,5-7 follicles or AMH ,0. 5 -1. 1 ng/ml).

Exclusion Criteria:

- women who suffer from any other cause of infertility other than poor ovarian reserve

- refusal of the patient to consent for using her data in the study.

Locations and Contacts

Kasr Al Aini, Cairo, Egypt
Additional Information

Starting date: July 2014
Last updated: August 8, 2015

Page last updated: August 23, 2015

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