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Functional Differences in Effortful Control

Information source: University of Michigan
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Methylphenidate (Drug); Placebo (Drug)

Phase: N/A

Status: Active, not recruiting

Sponsored by: University of Michigan

Official(s) and/or principal investigator(s):
Chandra Sekhar Sripada, MD, PhD, Principal Investigator, Affiliation: University of Michigan

Summary

The purpose of this study is to learn more about the brain circuits involved with effortful control in healthy adult participants. Study participants will be given either methylphenidate (also known as 'Ritalin')which is an FDA approved, most widely-used medication given to those diagnosed with Attention Deficit Hyperactivity Disorder (ADHD)or a placebo, which is a sugar pill. Each participant will also perform some computer tasks that have been shown in previous studies to require effortful control while undergoing an fMRI (functional Magnetic Resonance Imaging) which takes a special kind of picture of the brain. Our goal is to learn more about the brain mechanisms by which methylphenidate improves effortful control.

Clinical Details

Official title: Functional Differences in Effortful Control

Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Primary outcome: Reaction Time on the Multi-Source Interference Task

Secondary outcome:

Accuracy on the Multi-Source Interference Task

Reaction time variability on the Multi-Source Interference Task

Detailed description: This study involves two total visits. All visits are scheduled at the Rachel Upjohn Building on East Medical Campus of the University of Michigan. Participation in this study will end once the participant has completed both study visits which are a total of 4 hours. The first visit will require one to complete various questionnaires regarding behavior and general health and takes about 1 hour to complete. The second visit will be scheduled approximately 2 to 7 days after the first study visit and includes the fMRI scanning session. The second visit will last about 3 hours.

Eligibility

Minimum age: 18 Years. Maximum age: 35 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Right-handedness

Exclusion Criteria:

- Any clinically significant personal or family history of cardiac problems

- Any current Axis I psychiatric disorder (diagnosis as verified by the Structured

Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV)

- A previous adequate trial with methylphenidate (Ritalin)

- Currently taking any psychoactive medications

- Any clinically significant medical condition

- Any clinically significant neurological problem (seizures, tics, serious head injury)

- Contraindications to MRI (metal objects in body or claustrophobia)

- Currently pregnant or lactating

- Alcohol or substance abuse (current or in the past 2 years)

- Left-handedness or ambidextrous

- Liver or kidney disease

Locations and Contacts

Rachel Upjohn Building, East Medical Campus, Ann Arbor, Michigan 48109-2700, United States
Additional Information

Starting date: October 2013
Last updated: July 17, 2015

Page last updated: August 23, 2015

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