The main purpose of this study is to simulate if oxycodone and naltrexone combination
capsules (ALO-02) were to be tampered with by dissolving and then injecting intravenously
for the purpose of getting high.
Drug Liking: Area Under Effect Curve (AUE) From 0-1 HourDrug Liking: Area Under Effect Curve (AUE) From 0-8 Hours
High: Area Under Effect Curve (AUE) From 0-1 Hour
High: Area Under Effect Curve (AUE) From 0-8 Hours
Take Drug Again: Peak Effect (Emax)
Take Drug Again: Mean Effect (Emean)
Overall Drug Liking: Peak Effect (Emax)
Overall Drug Liking: Mean Effect (Emean)
Any Drug Effects: Area Under Effect Curve (AUE) From 0-1 Hour
Any Drug Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Any Drug Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Good Drug Effects: Area Under Effect Curve (AUE) From 0-1 Hour
Good Drug Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Good Drug Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Bad Drug Effects: Area Under Effect Curve (AUE) From 0-1 Hour
Bad Drug Effects: Area Under Effect Curve (AUE) From 0-2 Hours
Bad Drug Effects: Area Under Effect Curve (AUE) From 0-8 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-1 Hour
Feel Sick: Area Under Effect Curve (AUE) From 0-2 Hours
Feel Sick: Area Under Effect Curve (AUE) From 0-8 Hours
Nausea: Area Under Effect Curve (AUE) From 0-1 Hour
Nausea: Area Under Effect Curve (AUE) From 0-2 Hours
Nausea: Area Under Effect Curve (AUE) From 0-8 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-1 Hour
Sleepy: Area Under Effect Curve (AUE) From 0-2 Hours
Sleepy: Area Under Effect Curve (AUE) From 0-8 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-1 Hour
Dizzy: Area Under Effect Curve (AUE) From 0-2 Hours
Dizzy: Area Under Effect Curve (AUE) From 0-8 Hours
Any Drug Effects: Peak Effect (Emax)
Good Drug Effects: Peak Effect (Emax)
Bad Drug Effects: Peak Effect (Emax)
Feel Sick: Peak Effect (Emax)
Nausea: Peak Effect (Emax)
Sleepy: Peak Effect (Emax)
Dizzy: Peak Effect (Emax)
Pupillometry: Area Under Effect Curve (AUE) From 0-1 Hour
Pupillometry: Area Under Effect Curve (AUE) From 0-2 Hours
Pupillometry: Area Under Effect Curve (AUE) From 0-8 Hours
Pupillometry: Peak Effect (Emax)
Pupillometry: Time to Maximum (Peak) Effect (TEmax)
Drug Liking: Time to Maximum (Peak) Effect (TEmax)
High: Time to Maximum (Peak) Effect (TEmax)
Any Drug Effects: Time to Maximum (Peak) Effect (TEmax)
Good Drug Effects: Time to Maximum (Peak) Effect (TEmax)
Bad Drug Effects: Time to Maximum (Peak) Effect (TEmax)
Sleepy: Time to Maximum (Peak) Effect (TEmax)
Dizzy: Time to Maximum (Peak) Effect (TEmax)
Nausea: Time to Maximum (Peak) Effect (TEmax)
Feel Sick: Time to Maximum (Peak) Effect (TEmax)
Plasma Concentration of Oxycodone 5 Minutes Post-Dose (C5min)
Plasma Concentration of Oxymorphone 5 Minutes Post-Dose (C5min)
Plasma Concentration of Noroxycodone 5 Minutes Post-Dose (C5min)
Plasma Concentration of Naltrexone 5 Minutes Post-Dose (C5min)
Plasma Concentration of 6-beta-naltrexol 5 Minutes Post-Dose (C5min)
Plasma Decay Half-Life (t1/2) of Oxycodone
Plasma Decay Half-Life (t1/2) of Oxymorphone
Plasma Decay Half-Life (t1/2) of Noroxycodone
Plasma Decay Half-Life (t1/2) of Naltrexone
Plasma Decay Half-Life (t1/2) of 6-beta-naltrexol
Area Under the Oxycodone Concentration-Time Curve (AUC0-1h)
Area Under the Oxymorphone Concentration-Time Curve (AUC0-1h)
Area Under the Noroxycodone Concentration-Time Curve (AUC0-1h)
Area Under the Naltrexone Concentration-Time Curve (AUC0-1h)
Area Under the 6-beta-naltrexol Concentration-Time Curve (AUC0-1h)
Area Under the Oxycodone Concentration-Time Curve (AUC0-2h)
Area Under the Oxymorphone Concentration-Time Curve (AUC0-2h)
Area Under the Noroxycodone Concentration-Time Curve (AUC0-2h)
Area Under the Naltrexone Concentration-Time Curve (AUC0-2h)
Area Under the 6-beta-naltrexol Concentration-Time Curve (AUC0-2h)
Area Under the Oxycodone Concentration-Time Curve (AUC0-8h)
Area Under the Oxymorphone Concentration-Time Curve (AUC0-8h)
Area Under the Noroxycodone Concentration-Time Curve (AUC0-8h)
Area Under the Naltrexone Concentration-Time Curve (AUC0-8h)
Area Under the 6-beta-naltrexol Concentration-Time Curve (AUC0-8h)
Area Under the Curve From Time Zero to Last Quantifiable Oxycodone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable Oxymorphone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable Noroxycodone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable Naltrexone Concentration (AUClast)
Area Under the Curve From Time Zero to Last Quantifiable 6-beta-naltrexol Concentration (AUClast)
Area Under the Curve From Time Zero Extrapolated to Infinity (AUCinf) for Oxycodone
Area Under the Curve From Time Zero Extrapolated to Infinity (AUCinf) for Oxymorphone
Area Under the Curve From Time Zero Extrapolated to Infinity (AUCinf) for Noroxycodone
Area Under the Curve From Time Zero Extrapolated to Infinity (AUCinf) for Naltrexone
Area Under the Curve From Time Zero Extrapolated to Infinity (AUCinf) for 6-beta-naltrexol
Systemic Clearance (Cl) of Oxycodone
Systemic Clearance (Cl) of Oxymorphone
Systemic Clearance (Cl) of Noroxycodone
Systemic Clearance (Cl) of Naltrexone
Systemic Clearance (Cl) of 6-beta-naltrexol
Volume of Distribution at Steady State (Vss) for Oxycodone
Volume of Distribution at Steady State (Vss) for Oxymorphone
Volume of Distribution at Steady State (Vss) for Noroxycodone
Volume of Distribution at Steady State (Vss) for Naltrexone
Volume of Distribution at Steady State (Vss) for 6-beta-naltrexol
Minimum age: 18 Years.
Maximum age: 55 Years.
Gender(s): Both.