DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia

Information source: Massachusetts General Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Schizophrenia

Intervention: eszopiclone (Drug); placebo (Drug)

Phase: N/A

Status: Completed

Sponsored by: Massachusetts General Hospital

Official(s) and/or principal investigator(s):
Dara S. Manoach, PhD, Principal Investigator, Affiliation: Massachusetts General Hospital

Summary

This study will determine whether eszopiclone will normalize sleep patterns and restore sleep-dependent enhancement of motor skill learning in patients with schizophrenia. The investigators will compare subjects taking a placebo to those taking 3 mg of eszopiclone with regard to: sleep architecture and sleep latency as measured by actigraphy and polysomnography and sleep-dependent motor skill learning.

Clinical Details

Official title: Effects of Eszopiclone on Sleep-dependent Learning in Schizophrenia

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Primary outcome:

Overnight Change on Finger Tapping Task

Sleep Spindle Density During Stage 2 Sleep as Measured by Polysomnography

Eligibility

Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Clinically stable outpatients with DSM-IV diagnoses of Schizophrenia

Exclusion Criteria:

- History of neurologic or psychiatric disease other than schizophrenia

- Substance abuse or dependence within the past six months

- Other chronic medical conditions that affect sleep

- Pregnancy/breast feeding

- Hepatic impairment

- Treatment with metabolic inhibitors or inducers

Locations and Contacts

Mass General Hospital, Boston, Massachusetts 02114, United States
Additional Information

Starting date: September 2006
Last updated: August 26, 2014

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017