Antagonistic Interaction CB1-paracetamol
Information source: University Hospital, Clermont-Ferrand
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pain
Intervention: Rimonabant and Paracetamol and placebo (Drug)
Phase: Phase 1
Status: Recruiting
Sponsored by: University Hospital, Clermont-Ferrand Official(s) and/or principal investigator(s):
Dubray Claude, Pr, Principal Investigator, Affiliation: University Hospital, Clermont-Ferrand
Overall contact:
DUBRAY Claude, Pr, Phone: 04.73.17.84.10, Email: cdubray@chu-clermontferrand.fr
Summary
Evaluation of an possible inhibiting effect of Rimonabant on the analgesic effect of
Paracetamol in healthy volunteers
Clinical Details
Official title: Evaluation of the Interaction of Rimonabant (Antagonist of CB1 Receptor) on the Analgesic Effect of Paracetamol in Intravenous Administration
Study design: Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Crossover Assignment, Pharmacodynamics Study
Primary outcome: Pain's threshold with electrical stimulation (Pain Matcher).
Pain's threshold with mechanical stimulation (electronical Von Frey).
Secondary outcome: Plasmatic concentration of paracetamol or his metabolite with or without Rimonabant
Detailed description:
Double Blind, cross-over, randomized and controlled versus placebo, study in healthy
volunteers.
Eligibility
Minimum age: 18 Years.
Maximum age: 40 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Healthy volunteers
- between 18 and 40 years old
- written consent given
Exclusion Criteria:
- Rimonabant or paracetamol hypersensibility
- Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
- Concomitant medication
- Chronical diseases
Locations and Contacts
DUBRAY Claude, Pr, Phone: 04.73.17.84.10, Email: cdubray@chu-clermontferrand.fr
CIC-CPC, Clermont-Ferrand 63000, France; Not yet recruiting
Dubray Claude, Pr, Phone: 04.73.17.84.10, Email: cdubray@chu-clermontferrand.fr
CHU Clermont-Ferrand, Clermont-Ferrand 63003, France; Recruiting
Patrick Lacarin, Email: placarin@chu-clermontferrand.fr
Additional Information
Starting date: September 2008
Ending date: November 2009
Last updated: October 1, 2009
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