Examining the Long-Term Risks of Oophorectomy
Information source: Parker, William H., M.D.
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Coronary Heart Disease; Stroke; Breast Cancer; Ovarian Cancer; Cancer; Hip Fracture; Death
Phase: N/A
Status: Completed
Sponsored by: Parker, William H., M.D. Official(s) and/or principal investigator(s):
William H Parker, MD, Principal Investigator, Affiliation: John Wayne Cancer Institute
Summary
At the time of hysterectomy for benign disease, the overall health benefits of preserving
ovarian function in a large population of women have not been established.
Clinical Details
Official title: Ovarian Conservation: Long-Term Health Outcomes From the Nurse's Health Study.
Study design: Observational Model: Cohort, Time Perspective: Prospective
Primary outcome: mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.
Secondary outcome: The effect of postmenopausal hormone use on mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.
Detailed description:
We are conducting a prospective, observational study of 32,175 women participants of the
Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are
evaluating mortality and morbidity due to the following conditions: coronary heart disease,
stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.
Eligibility
Minimum age: 30 Years.
Maximum age: 55 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Women who had hysterectomies were classified into simple hysterectomy or hysterectomy
with both ovaries removed.
Exclusion Criteria:
- Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip
fracture before entering the study were excluded. Cancer as an indication for
hysterectomy also excluded.
- Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of
hysterectomy, or those who had oophorectomy before hysterectomy were excluded.
Locations and Contacts
Parker, Rosenman, Rodi Gynecology Group, Santa Monica, California 90401, United States
Additional Information
Related publications: Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol. 2005 Aug;106(2):219-26.
Starting date: January 1980
Last updated: April 8, 2008
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