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Examining the Long-Term Risks of Oophorectomy

Information source: Parker, William H., M.D.
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Coronary Heart Disease; Stroke; Breast Cancer; Ovarian Cancer; Cancer; Hip Fracture; Death

Phase: N/A

Status: Completed

Sponsored by: Parker, William H., M.D.

Official(s) and/or principal investigator(s):
William H Parker, MD, Principal Investigator, Affiliation: John Wayne Cancer Institute

Summary

At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.

Clinical Details

Official title: Ovarian Conservation: Long-Term Health Outcomes From the Nurse's Health Study.

Study design: Observational Model: Cohort, Time Perspective: Prospective

Primary outcome: mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Secondary outcome: The effect of postmenopausal hormone use on mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Detailed description: We are conducting a prospective, observational study of 32,175 women participants of the Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are evaluating mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Eligibility

Minimum age: 30 Years. Maximum age: 55 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Women who had hysterectomies were classified into simple hysterectomy or hysterectomy

with both ovaries removed. Exclusion Criteria:

- Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip

fracture before entering the study were excluded. Cancer as an indication for hysterectomy also excluded.

- Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of

hysterectomy, or those who had oophorectomy before hysterectomy were excluded.

Locations and Contacts

Parker, Rosenman, Rodi Gynecology Group, Santa Monica, California 90401, United States
Additional Information

Related publications:

Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol. 2005 Aug;106(2):219-26.

Starting date: January 1980
Last updated: April 8, 2008

Page last updated: August 23, 2015

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