Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard
Information source: Baqiyatallah Medical Sciences University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Bronchiolitis; Chronic Bronchitis
Intervention: helium:oxygen mixture (Drug)
Phase: Phase 2/Phase 3
Status: Completed
Sponsored by: Baqiyatallah Medical Sciences University
Summary
to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease
dyspnea and improve physiologic and respiratory measures in patients with a previous
exposure to Sulfur Mustard gas.
Clinical Details
Official title: Helium:Oxygen Versus Air:Oxygen Nonivasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care
Eligibility
Minimum age: 38 Years.
Maximum age: 59 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- exposure to sulfur mustard
- worsening dyspnea during the last 10 days
- respiratory rate of >25/min
- arterial pH<7. 35
- PaCO2 of >50 mmHg
- PaO2 of <50 mmHg
Exclusion Criteria:
- recent pneumothorax (<1 month)
- severe respiratory failure or hemodynamic instability with forthcoming intubation
- FIO2 of <0. 4
- impaired consciousness or absence of patient cooperation
- facial lesions precluding NIPPV
Locations and Contacts
BMSU, Tehran 19945-546, Iran, Islamic Republic of
Additional Information
Starting date: April 2007
Last updated: March 24, 2008
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