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Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Information source: Baqiyatallah Medical Sciences University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Bronchiolitis; Chronic Bronchitis

Intervention: helium:oxygen mixture (Drug)

Phase: Phase 2/Phase 3

Status: Completed

Sponsored by: Baqiyatallah Medical Sciences University

Summary

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

Clinical Details

Official title: Helium:Oxygen Versus Air:Oxygen Nonivasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care

Eligibility

Minimum age: 38 Years. Maximum age: 59 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- exposure to sulfur mustard

- worsening dyspnea during the last 10 days

- respiratory rate of >25/min

- arterial pH<7. 35

- PaCO2 of >50 mmHg

- PaO2 of <50 mmHg

Exclusion Criteria:

- recent pneumothorax (<1 month)

- severe respiratory failure or hemodynamic instability with forthcoming intubation

- FIO2 of <0. 4

- impaired consciousness or absence of patient cooperation

- facial lesions precluding NIPPV

Locations and Contacts

BMSU, Tehran 19945-546, Iran, Islamic Republic of
Additional Information

Starting date: April 2007
Last updated: March 24, 2008

Page last updated: August 23, 2015

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