Sorafenib and pazopanib are both effective and promising treatments for advanced Renal Cell
Carcinoma (RCC). Both drugs are registered for this indication. No prospective comparative
data in advanced RCC (or other indications) have been published. A search in the
clinicaltrials. gov database did not reveal any planned or ongoing studies. As sequential
therapy is now the standard of treatment for advanced RCC it is important to evaluate in
clinical trials what the value of different sequential strategies is. This needs to be done
every time new agents are introduced into the treatment armamentarium. As there are no data
yet on the sequential use of sorafenib followed by pazopanib or vice versa, this sequence,
however, will most certainly be used in daily practice, it is required to examine efficacy
and safety of this sequential approach in a clinical trial in a randomized setting.
Therefore, the investigators have designed an open randomized study in patients not
previously treated for advanced RCC. Suitable patients will be randomized (1: 1) in 2 groups.
Minimum age: 18 Years.
Maximum age: 85 Years.
Gender(s): Both.
Stefan Feldner, Dr., Phone: +49(0) 761 / 152 42-19, Email: stefan.feldner@iomedico.com
Medizinische Universität Innsbruck, Innsbruck 6020, Austria; Completed
A. ö. Bezirkskrankenhaus Kufstein, Kufstein 6330, Austria; Recruiting
Email: lorenz.hoeltl@bkh-kufstein.at
Lorenz Höltl, Dr., Principal Investigator
AKH Linz GmbH, Linz 4020, Austria; Recruiting
Email: steffen.krause@akh.linz.at
Steffen Krause, Dr., Principal Investigator
LKH Salzburg, Salzburg 5020, Austria; Recruiting
Email: g.janetschek@salk.at
Günter Janetschek, Prof. Dr., Principal Investigator
Universitätsklinikum Aachen, Urologische Klinik, Aachen 51074, Germany; Recruiting
Email: bbrehmer@ukaachen.de
Bernhard Brehmer, Dr., Principal Investigator
Gesundheitszentrum St. Marien GmbH, Amberg 92224, Germany; Recruiting
Email: weikersthal.ludwig@gesundheitszentrum.klinikum-amberg.de
Ludwig Fischer von Weikersthal, Dr., Principal Investigator
Charite Campus Virchow Klinikum / Klein. Für Innere Med / Onkologie/Hämatologie, Berlin 13353, Germany; Recruiting
Email: jorg.westermann@charite.de
Jörg Westermann, Dr., Principal Investigator
Praxis für Urologie, Berlin 13055, Germany; Recruiting
Email: dr.wolfgang.hoelzer@gmx.de
Wolfgang Hölzer, Dr., Principal Investigator
Gemeinschaftspraxis Pott / Tirier / Hannig - Onkologie, Bottrop 46236, Germany; Recruiting
Email: c.hannig@email.de
Carla V Hannig, Dr., Principal Investigator
Urologie im Schlosscarrée Braunschweig, Braunschweig 38100, Germany; Recruiting
Email: Junius@urologie-schlosscarree.de
Harald Junius, Dr., Principal Investigator
Klinikum Bremen-Mitte gGmbH, Bremen 28177, Germany; Completed
Bethanien Krankenhaus Chemnitz gGmbH, Chemnitz 09130, Germany; Recruiting
Email: h.belz@bethanien-sachsen.de
Hanjo Belz, Dr., Principal Investigator
Onkologische Gemeinschaftspraxis Dörfel/Göhler, Dresden 01127, Germany; Recruiting
Email: thomas.goehler@dgn.de
Thomas Göhler, Dr., Principal Investigator
Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Dresden 01307, Germany; Recruiting
Email: manfred.wirth@uniklinikum-dresden.de
Manfred Wirth, Prof. Dr., Principal Investigator
Urologische Gemeinschaftspraxis, Duisburg 47179, Germany; Recruiting
Email: hellmis@urologo.de
Eva Hellmis, Dr., Principal Investigator
Krankenhaus Düren gGmbH, Düren 52351, Germany; Not yet recruiting
Email: christof.boergermann@krankenhaus-dueren.de
Christof Börgermann, Dr., Principal Investigator
Universitätsklinikum Düsseldorf, Düsseldorf 40225, Germany; Recruiting
Email: markus.giessing@med.uni-duesseldorf.de
Markus Giessing, Dr., Principal Investigator
Urologie Neandertal - Ortsübergreifende Gemeinschaftspraxis für Urologie, Erkrath 40699, Germany; Completed
Waldkrankenhaus St. Marien, Erlangen 91054, Germany; Recruiting
Email: peter.goebell@uk-erlangen.de
Peter J Goebell, Dr., Principal Investigator
St.-Antonius-Hospital in Eschweiler / Klinik f. Hämatologie und Onkologie, Eschweiler 52249, Germany; Recruiting
Email: onk@sah-eschweiler.de
Peter Staib, Dr., Principal Investigator
Hämato-onkologische Gemeinschaftspraxis, Essen 45136, Germany; Recruiting
Email: praxis@onkologie-essen.de
Ulla Frfr. von Verschuer, Dr., Principal Investigator
Onkozentrum Freiberg, Freiberg 09599, Germany; Not yet recruiting
Email: boldt@onkozentrum.de
Thomas Boldt, Principal Investigator
Praxis für interdisziplinäre Onkologie & Hämatologie, Freiburg 79106, Germany; Recruiting
Email: zaiss@onkologie-freiburg.de
Matthias Zaiss, Dr., Principal Investigator
Universitätsklinikum Freiburg, Freiburg 79106, Germany; Recruiting
Email: christian.leiber@uniklinik-freiburg.de
Christian Leiber, Dr., Principal Investigator
MVZ Osthessen GmbH, Fulda 36043, Germany; Recruiting
Email: Silke.Schirrmacher-Memmel@klinikum-fulda.de
Silke Schirrmacher-Memmel, Dr., Principal Investigator
Gem.praxis Dres. J. Wilke, H. Wagner - Hämatol.u.intern.Onkol. am Klinikum Fürth, Fürth 90766, Germany; Not yet recruiting
Email: info@onkologie-fuerth.de
Jochen Wilke, Dr., Principal Investigator
Onkologische Schwerpunktpraxis, Goslar 38642, Germany; Recruiting
Email: studien@onkologie-goslar.de
Hans W Tessen, Dr., Principal Investigator
Universitätsmedizin Greifswald, Greifswald 17475, Germany; Recruiting
Email: ziuro@uni-greifswald.de
Uwe Zimmermann, Dr., Principal Investigator
St. Antonius-Hospital Gronau GmbH, Gronau 48599, Germany; Recruiting
Email: witt@st-antonius-gronau.de
Jörn Witt, Dr., Principal Investigator
Universitätsklinikum Göttingen, Göttingen 37075, Germany; Recruiting
Email: astrauss@med.uni-goettingen.de
Arne Strauß, Dr., Principal Investigator
Asklepios Klinik Altona, Hamburg 22763, Germany; Recruiting
Email: c.wuelfing@asklepios.com
Christian Wülfing, Prof. Dr., Principal Investigator
Onkologische Schwerpunktpraxis, Hamburg 20095, Germany; Recruiting
Email: jwierecky@gmx.de
Jan Wierecky, Dr., Principal Investigator
Universitätsklinikum Heidelberg, Klinik für Urologie, Heidelberg 69120, Germany; Recruiting
Email: sascha.pahernik@med.uni-heidelberg.de
Sascha Pahernik, Dr., Principal Investigator
Urologie-Heinsberg, Heinsberg 52525, Germany; Recruiting
Email: kretz@urologie-heinsberg.de
Thomas Kretz, Principal Investigator
Onkologische Praxis, Hildesheim 331135, Germany; Recruiting
Email: dr.freier@onkologie-hildesheim.de
Werner Freier, Dr., Principal Investigator
Universitätsklinikum des Saarlandes, Homburg 66421, Germany; Recruiting
Email: Carsten.Ohlmann@uks.eu
Carsten-Henning Ohlmann, Dr., Principal Investigator
Universitätsklinikum Jena, Klinik für Urologie, Jena 07743, Germany; Recruiting
Email: marc-oliver.grimm@med.uni-jena.de
Marc O Grimm, Prof., Principal Investigator
Überörtliche Gemeinschaftspraxis, Köln 50968, Germany; Not yet recruiting
Email: info@drklier.de
Jörg Klier, Dr., Principal Investigator
Praxis für Urologie, Lauenburg 21481, Germany; Not yet recruiting
Email: Dr.Simson@t-online.de
Gabriele Simson, Dr., Principal Investigator
Onkologische Schwerpunktpraxis Leer - Emden, Leer 26789, Germany; Recruiting
Email: lothar.mueller@onkologie-leer.de
Lothar Müller, Dr., Principal Investigator
MVZ Mitte/ MVZ Delitzsch GmbH, Leipzig 04103, Germany; Completed
Urologische Facharztpraxis, Lutherstadt Eisleben 06295, Germany; Recruiting
Email: R.Eckert@onlinemed.de
Ralf Eckert, Dr., Principal Investigator
Universitätsklinikum Magdeburg A.ö.R, Magdeburg 39120, Germany; Recruiting
Email: martin.schostak@med.ovgu.de
Martin Schostak, Prof. Dr., Principal Investigator
Universitätsklinik Mannheim, Mannheim 68167, Germany; Recruiting
Email: christian.bolenz@medma.uni-heidelberg.de
Philips-Universität-Marburg, Urologie und Kinderurologie, Marburg 35043, Germany; Recruiting
Email: Hegele@med.uni-marburg.de
Axel Hegele, Dr., Principal Investigator
Praxis Markkleeberg, Markkleeberg 04416, Germany; Not yet recruiting
Email: m.schulze@praxis-schulze.de
Matthias Schulze, Dr., Principal Investigator
Kliniken Maria Hilf, Mönchengladbach 41063, Germany; Not yet recruiting
Email: herbert.sperling@mariahilf.de
Herbert Sperling, Prof. Dr., Principal Investigator
PUR/R Praxisklinik Urologie Rhein Rhur, Mühlheim 45458, Germany; Not yet recruiting
Email: a.eisenhardt@pur-r.de
Andreas Eisenhardt, Dr., Principal Investigator
Klinikum r. d. Isar, Klinik für Urologie, München 81675, Germany; Recruiting
Margitta Retz, Dr., Email: Margitta.Retz@lrz.tu-muenchen.de
Margitta Retz, Dr., Principal Investigator
Universitätsklinikum Münster , Klinik für Urologie, Münster 48149, Germany; Recruiting
Email: Edwin.Herrmann@ukmuenster.de
Edwin Herrmann, Dr., Principal Investigator
Eps- early phase solutions GmbH, Pößneck, Germany; Not yet recruiting
Email: klaus.ruffert@eps-earlyphase.com
Klaus Ruffert, Dr., Principal Investigator
Caritas Krankenhaus St. Josef, Regensburg 93053, Germany; Recruiting
Email: sdenzinger@gmx.de
Stefan Denzinger, Dr., Principal Investigator
Universitätsklinikum Rostock, Rostock 18055, Germany; Recruiting
Email: oliver.hakenberg@med.uni-rostock.de
Oliver Hakenberg, Prof. Dr., Principal Investigator
Zentrum für Urologie und Onkologie, Rostock 18107, Germany; Recruiting
Andreas Huebner, Dr., Principal Investigator
Diakoniekrankenhaus Rotenburg (Wümme) gGmbH, Rotenburg (Wümme) 27356, Germany; Not yet recruiting
Email: muschter@diako-online.de
Rolf Muschter, Prof. Dr., Principal Investigator
Klinikum Sindelfingen-Böblingen, Sindelfingen 71065, Germany; Recruiting
Email: t.knoll@klinikverbund-suedwest.de
Thomas Knoll, Prof. Dr., Principal Investigator
Marienhospital / Innere Med III Onko Hämato Palliativm, Stuttgart 70199, Germany; Recruiting
Email: ClaudioDenzlinger@vinzenz.de
Claudio Denzlinger, Prof., Principal Investigator
Eberhard-Karls-Universität Tübingen, Tübingen 72076, Germany; Recruiting
Email: bedke@live.com
Jens Bedke, Dr., Principal Investigator
Universitätsklinik Ulm, Ulm 89075, Germany; Recruiting
Email: thomas.schnoeller@uniklinik-ulm.de
Thomas Schnöller, Dr., Principal Investigator
Universitätsklinikum Ulm, Ulm 89081, Germany; Recruiting
Email: jochen.greiner@uniklinik-ulm.de
Jochen Greiner, Prof. Dr., Principal Investigator
Praxis für Hämatologie und internistische Onkologie, Velbert 42551, Germany; Not yet recruiting
Email: nusch@aol.com
Arnd Nusch, Dr., Principal Investigator
Klinikum Nordoberpfalz AG, Weiden 92637, Germany; Not yet recruiting
Email: theodor.klotz@kliniken-nordoberpfalz.ag
Theodor Klotz, Prof. Dr., Principal Investigator
Gesellsch. z. Förd. Von Wissenschaft u.Qualitätssicherung i.d.ambul.Onkologie, Wiesbaden 65191, Germany; Recruiting
Email: josten.haema-onko@dkd-wiesbaden.de
Klaus M Josten, Dr., Principal Investigator
Praxisgemeinschaft für Onkologie und Urologie, Wilhelmshaven 26389, Germany; Recruiting
Email: yrodemer@yahoo.com
Yolanda Rodemer, Principal Investigator
Gemeinschaftspraxis für Urologie, Wuppertal 42103, Germany; Recruiting
Email: jgleissner@dgu-team.de
Jochen Gleißner, Dr., Principal Investigator
Universitätsklinikum Würzburg, Würzburg 97080, Germany; Recruiting
Email: burger_m2@klinik.uni-wuerzburg.de
Maximilian Burger, Dr., Principal Investigator
Onze Lieve Vrouwe Gasthuis, Amsterdam 1091 HA, Netherlands; Recruiting
Email: j.m.meerumterwogt@olvg.nl
Jetske M Meerum Terwogt, Principal Investigator
Reinier de Graaf Gasthuis, Delft 2600 AG, Netherlands; Recruiting
Email: bos@rdgg.nl
Monique M.E.M. Bos, Principal Investigator
HAGA, Den Haag 2545, Netherlands; Recruiting
Houtsma, Dr., Principal Investigator
Spaarne Ziekenhuis, Hoofddorp 2130 AT, Netherlands; Recruiting
Email: abeeker@spaarneziekenhuis.nl
Aart Beeker, Dr., Principal Investigator
TweeSteden Ziekenhuis, Tilburg 5042 AD, Netherlands; Recruiting
Email: sgoey@tsz.nl
Swan H Goey, Dr., Principal Investigator
VieCuri Medical Center, Venlo 5912 BL, Netherlands; Recruiting
Email: yvdwouw@viecuri.nl
Agnes J van de Wouw, Dr., Principal Investigator