Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Information source: University of Michigan
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Irreversible Pulpitis
Intervention: Articaine local anesthetic (Drug); Lidocaine local anesthetic (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: University of Michigan Official(s) and/or principal investigator(s):
Mathilde C Peters, DMD, PhD, Study Chair, Affiliation: University of Michigan
Summary
The purpose of this study is to study the ability of a frequently used dental anesthetic
(articaine) to achieve complete numbness of a diseased tooth with the most commonly used
injection technique in the lower jaw (inferior alveolar nerve block: IANB). If this
technique fails, a commonly used supplemental technique with one of two possible dental
anesthetics (lidocaine or articaine) will be given to evaluate the success/failure of
complete numbness between the two anesthetics.
The investigators hypothesize that supplemental infiltration anesthesia with articaine will
give the same success rate as lidocaine in achieving complete pulpal anesthesia in
mandibular molars with irreversible pulpitis.
Clinical Details
Official title: Articaine Versus Lidocaine Supplemental Infiltration Efficacy in Irreversible Pulpitis Mandibular Molars After Failed Inferior Alveolar Nerve Block
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: Anesthetic success rate of supplemental infiltration injection
Secondary outcome: Anesthetic success rate of an IANB with articaine
Detailed description:
The goal of the study is to achieve complete pulpal anesthesia in irreversible pulpitis
mandibular molars, either by IANB administration of 4% articaine with 1: 100,000 epinephrine
(NDA 022466), or in case the IANB appeared to be clinically unsuccessful by supplemental
infiltration of either articaine or lidocaine.
The investigators hypothesize that an inferior alveolar nerve block with articaine in
irreversible pulpitis mandibular molars will yield a complete pulpal success rate greater
than 30 percent.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- adult patients
- irreversible pulpitis in mandibular molar
Exclusion Criteria:
- below 18 years
Locations and Contacts
University of Michigan, School of Dentistry Clinics, Ann Arbor, Michigan 48109, United States
Additional Information
Related publications: Brandt RG, Anderson PF, McDonald NJ, Sohn W, Peters MC. The pulpal anesthetic efficacy of articaine versus lidocaine in dentistry: a meta-analysis. J Am Dent Assoc. 2011 May;142(5):493-504.
Starting date: September 2011
Last updated: July 24, 2013
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