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Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma

Information source: St. Joseph's Hospital and Medical Center, Phoenix
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Ventilator Associated Pneumonia

Intervention: Chlorhexidine gluconate (Drug); Toothpaste (Other)

Phase: N/A

Status: Completed

Sponsored by: St. Joseph's Hospital and Medical Center, Phoenix

Official(s) and/or principal investigator(s):
Tracy Thomas, MSN, Principal Investigator, Affiliation: St. Joseph's Hospital and Medical Center, Phoenix


Examine the use of 0. 12% Chlorhexidine Gluconate as an adjunct to current oral care protocol for trauma patients on ventilator support to decrease the incidence of Ventilator Associated Pneumonia and oral bacterial load.

Clinical Details

Official title: Evaluating Effectiveness of Chlorhexidine Gluconate Oral Care for Adults

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Effectiveness of Chlorhexidine Gluconate Oral Care for Trauma Patients

Detailed description: To see a significant decrease in the bacterial load in the oral mucosa and subsequently, a decrease in the pathogenesis of Ventilator Associated Pneumonia through the use of an oral rinse containing 0. 12% Chlorhexidine Gluconate as part of an oral care protocol. Current oral care protocol includes the use of 1. 5% H2O2-coated swabs every four hours, toothbrushing with toothpaste every 12 hours, and use of continuous subglottic suction apparatus.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Adults admitted to ICUs located in Tower Two Critical Care Units: Medical, Surgical,

Medical #2, and Trauma Intensive Care Units.

- Patients will be randomized to either treatment or standard group based on day of

admission to Intensive Care Units. No limitation regarding gender, race, and ethnicity so that the sample will reflect "typical" Trauma population. Exclusion Criteria:

- All patients admitted under "Doe" Status

- All patients with acute cervical spine injuries or facial fractures that oral care

will create further harm to the patient (physician order stating "no oral care to be given" will be in chart)

- All patients with Oral Trauma or Oral Surgery

- All minors (Study will be completed in Adult Critical Care Units)

- Patients with allergy to chlorhexidine

- Patients without Teeth, or with fewer than 6 teeth

Locations and Contacts

St. Joseph's Hospital and Medical Center, Phoenix, Arizona 85013, United States
Additional Information

Starting date: July 2010
Last updated: December 5, 2013

Page last updated: August 23, 2015

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