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Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community

Information source: University of Pennsylvania
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: MRSA - Methicillin Resistant Staphylococcus Aureus Infection

Intervention: MRSA decolonization (Drug)

Phase: N/A

Status: Completed

Sponsored by: Ebbing Lautenbach

Official(s) and/or principal investigator(s):
Ebbing Lautenbach, MD, Principal Investigator, Affiliation: University of Pennsylvania

Summary

The overall goal of this project is to elucidate the epidemiology of MRSA transmission in the community and test an intervention to prevent MRSA transmission in this setting.

Clinical Details

Official title: Epidemiology and Prevention of MRSA Transmission in the Community

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Primary outcome: New MRSA infection

Detailed description: The overall goals of this project are to: 1. to investigate the determinants of and evaluate potential interventions to reduce the spread of methicillin resistant Staphylococcus aureus (MRSA) infections in community settings in order to reduce the burden of this illness in the State of Pennsylvania. This objective has the following specific aims:

- to identify host, microbiological and environmental risk factors for prolonged

MRSA colonization, MRSA transmission and clinical MRSA infection among patients with MRSA skin and soft tissue infections (SSTIs) and their household contacts and to use stochastic agent-based modeling methods to quantify secondary spread of CO-MRSA in households.

- to evaluate the impact of a decolonization intervention on MRSA infections in the

household.

- to identify immunological mechanisms underlying the ability of Streptococcus

pneumoniae colonization to inhibit MRSA colonization, transmission and infection in order to identify potential future immunological targets for interventions. 2. to foster multi-disciplinary and cross-institutional collaborations and develop the infrastructure for a Center of Excellence focused on antimicrobial drug resistance research, with the capacity for activities linking basic science, epidemiological and clinical intervention studies 3. to enhance opportunities for basic and clinical research training for undergraduate and graduate students, particularly from underrepresented minorities, in order to increase the pipeline of future biomedical scientists and clinical investigators

Eligibility

Minimum age: 6 Months. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- All members of a household in which the index case is treated for a skin or soft

tissue infection due to MRSA. All household members must agree to participate in order for the household to be enrolled Exclusion Criteria:

- Prior MRSA within past 6 months in the index case; age less than 6 months.

Locations and Contacts

Hershey Medical Center, Hershey, Pennsylvania 17033, United States

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

Penn Presbyterian Medical Center, Philadelphia, Pennsylvania 19104, United States

Additional Information

Starting date: September 2009
Last updated: February 3, 2014

Page last updated: August 23, 2015

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