Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community
Information source: University of Pennsylvania
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: MRSA Infection/Colonization
Intervention: MRSA decolonization (Drug)
Phase: N/A
Status: Not yet recruiting
Sponsored by: University of Pennsylvania Official(s) and/or principal investigator(s):
Ebbing Lautenbach, MD, Principal Investigator, Affiliation: University of Pennsylvania
Overall contact:
Pam Tolomeo, MPH, Phone: 215-573-7763, Email: tolomeop@mail.med.upenn.edu
Summary
The overall goal of this project is to elucidate the epidemiology of MRSA transmission in
the community and test an intervention to prevent MRSA transmission in this setting.
Clinical Details
Official title: Epidemiology and Prevention of MRSA Transmission in the Community
Study design: Prevention, Randomized, Open Label, Placebo Control, Parallel Assignment, Efficacy Study
Primary outcome: New MRSA infection
Detailed description:
The overall goals of this project are to:
1. to investigate the determinants of and evaluate potential interventions to reduce the
spread of methicillin resistant Staphylococcus aureus (MRSA) infections in community
settings in order to reduce the burden of this illness in the State of Pennsylvania.
This objective has the following specific aims:
- to identify host, microbiological and environmental risk factors for prolonged
MRSA colonization, MRSA transmission and clinical MRSA infection among patients
with MRSA skin and soft tissue infections (SSTIs) and their household contacts and
to use stochastic agent-based modeling methods to quantify secondary spread of
CO-MRSA in households.
- to evaluate the impact of a decolonization intervention on MRSA infections in the
household.
- to identify immunological mechanisms underlying the ability of Streptococcus
pneumoniae colonization to inhibit MRSA colonization, transmission and infection
in order to identify potential future immunological targets for interventions.
2. to foster multi-disciplinary and cross-institutional collaborations and develop the
infrastructure for a Center of Excellence focused on antimicrobial drug resistance
research, with the capacity for activities linking basic science, epidemiological and
clinical intervention studies
3. to enhance opportunities for basic and clinical research training for undergraduate and
graduate students, particularly from underrepresented minorities, in order to increase
the pipeline of future biomedical scientists and clinical investigators
Eligibility
Minimum age: 6 Months.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- All members of a household in which the index case is treated for a skin or soft
tissue infection due to MRSA. All household members must agree to participate in
order for the household to be enrolled
Exclusion Criteria:
- Prior MRSA within past 6 months in the index case; age less than 6 months.
Locations and Contacts
Pam Tolomeo, MPH, Phone: 215-573-7763, Email: tolomeop@mail.med.upenn.edu Additional Information
Starting date: September 2009
Ending date: June 2013
Last updated: August 26, 2009
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