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The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation

Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Heart Disease

Intervention: Forearm Venous Occlusion Plethysmography (Procedure)

Phase: N/A

Status: Completed

Sponsored by: University of Edinburgh

Official(s) and/or principal investigator(s):
Anders Blomberg, MD, Principal Investigator, Affiliation: Umeå University

Summary

The purpose of this study is to determine whether a retrofit particle trap can reduce the adverse vascular responses to diesel exhaust inhalation

Clinical Details

Official title: The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: Forearm blood flow in response to infused intra-arterial vasodilators

Secondary outcome:

Arterial stiffness measured by applanation tonometry

Thrombogenicity measured using the Badimon chamber - an ex-vivo model of thrombosis under conditions of continuous flow

Exhaled nitric oxide - a marker of pulmonary inflammation

Endogenous fibrinolytic capacity - measured as net release of t-PA in response to infused bradykinin

Biochemical markers of systemic inflammation

Detailed description: 18 subjects healthy male volunteers will be recruited at UmeŚ University. In a randomised, double blind 3 way crossover trial, subjects will be exposed to filtered air, diesel exhaust (300mcg/m3) or filtered diesel exhaust for 1 hour during intermittent exercise.

2 hours following the exposure, thrombogenicity will be assessed using the Badimon chamber -

an ex-vivo model of thrombosis formed under constant flow conditions. Forearm blood flow in response to infused intra-brachial vasodilators will be measured using venous occlusion plethysmography 6 hours after the exposure. Arterial stiffness will be measured using peripheral arterial applanation tonometry in the hour post-exposure. Blood samples will be collected at timepoints over the 24 hours after exposure.

Eligibility

Minimum age: 18 Years. Maximum age: 35 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Healthy male volunteers

Exclusion Criteria:

- Intercurrent illness

- Smoking

- Significant occupational exposure to air pollution

- Regular medication usage

Locations and Contacts

Umeå University, Umeå, Västerbottens SE-901 87, Sweden
Additional Information

Starting date: September 2007
Last updated: September 4, 2008

Page last updated: August 23, 2015

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